Randomised multicenter phase II study of two schedules of docetaxel and gemcitabine or cisplatin/gemcitabine followed by docetaxel as first line treatment for advanced non-small cell lung cancer.

Author: CrinòLucio, De MarinisFilippo, FalconeAlfredo, GrassivaroNicoletta, NardiMario, NovelloSilvia, RinaldiMassimo, RussoFrancesca, ScagliottiGiorgio Vittorio, TibaldiCarmelo, TinazziAngelo, TonatoMaurizio

Paper Details 
Original Abstract of the Article :
BACKGROUND: In the attempt to optimize the efficacy of chemotherapy in advanced non-small cell lung cancer (NSCLC) several strategies need to be investigated including the use of non-platinum combinations and the sequential use of different agents. PATIENTS AND METHODS: In a phase II randomised stu...See full text at original site
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引用元:
https://doi.org/10.1016/j.lungcan.2009.02.009

データ提供:米国国立医学図書館(NLM)

Randomised Multicenter Phase II Study of Two Schedules of Docetaxel and Gemcitabine or Cisplatin/Gemcitabine Followed by Docetaxel as First Line Treatment for Advanced Non-Small Cell Lung Cancer

The fight against [advanced non-small cell lung cancer (NSCLC)] is a challenging endeavor, with researchers constantly seeking new and effective treatment strategies. This study delves into the efficacy of various [chemotherapy regimens] in treating [advanced NSCLC]. It's like exploring a vast desert, where each path represents a different treatment option, and the goal is to find the one that leads to the most successful outcome.

The researchers conducted a [phase II randomized study] involving [165 patients] with [stage IIIB or IV NSCLC]. They compared three different treatment arms: [docetaxel and gemcitabine], [docetaxel and gemcitabine], and [gemcitabine plus cisplatin followed by docetaxel]. This study sought to identify the most effective regimen by comparing their impact on [overall response rate, progression-free survival, and overall survival]. It's like comparing different caravan routes across the desert, seeking the one that provides the safest and most efficient passage.

The Importance of Finding the Right Treatment Path

The study found that [none of the tested combinations showed a clear superior efficacy] according to the planned statistical design. This suggests that further investigation and exploration are needed to identify the most effective treatment approaches for [advanced NSCLC]. It's like realizing that none of the paths across the desert are perfect, and more exploration is needed to find the optimal route.

The Ongoing Search for Better Treatments

The findings underscore the importance of ongoing research to develop more effective and targeted therapies for [advanced NSCLC]. It's like continuing to explore the desert, searching for new oases and pathways that can lead to better treatment options for patients. The journey towards finding a cure is long and arduous, but with continued dedication and innovation, we can hope to find a solution.

Dr.Camel's Conclusion

This study highlights the complex nature of treating [advanced NSCLC] and the ongoing need for research to develop better treatment options. It's like navigating a vast and unforgiving desert, where each step forward requires careful consideration and a commitment to finding the right path. As researchers, we must continue to explore new territories, seeking solutions that can bring hope and relief to patients.

Date :
  1. Date Completed 2010-06-08
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

19329221

DOI: Digital Object Identifier

10.1016/j.lungcan.2009.02.009

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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