Systemic treatment in severe cases of recurrent aphthous stomatitis: an open trial.

Author: HirotaSilvio Kenji, MigliariDante Antonio, MimuraMaria Angela Martins, SanchesJosé Antonio, SugayaNorberto Nobuo

Paper Details 
Original Abstract of the Article :
PURPOSE: This study aimed to evaluate the efficacy of the systemic drugs thalidomide, dapsone, colchicine, and pentoxifylline in the treatment of severe manifestations of RAS. METHODS: An open, 4-year clinical trial was carried out for 21 consecutive patients with severe RAS. Initially, patients we...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2666466/

データ提供:米国国立医学図書館(NLM)

Systemic Treatment of Recurrent Aphthous Stomatitis: A Search for Relief

The world of [oral medicine] is a desert where [recurrent aphthous stomatitis (RAS)] can create discomfort and pain. This study, like a dedicated clinician seeking relief for their patients, explored the effectiveness of [systemic drugs] for [treating severe manifestations of RAS]. The researchers, using an [open clinical trial], aimed to [evaluate the efficacy of thalidomide, dapsone, colchicine, and pentoxifylline] in [managing RAS symptoms]. Their findings reveal [that thalidomide was the most effective and well-tolerated drug], leading to [complete remission] in a significant portion of patients. This study offers a beacon of hope for patients struggling with RAS, providing a potential path to symptom relief. The key takeaway is that [thalidomide may be an effective treatment option for severe RAS].

Finding Relief in the Desert of RAS

The study found that [thalidomide significantly reduced RAS symptoms] and led to [complete remission] in many patients. This is like a camel finding a cool spring in the desert, bringing a much-needed reprieve from the heat and dryness. The findings also indicate that [dapsone, colchicine, and pentoxifylline] provided [benefit] for some patients, offering additional options for [managing RAS symptoms].

Navigating the Desert of Oral Discomfort

This research offers a valuable resource for clinicians treating patients with [RAS]. It's like finding a new route through a challenging desert, providing a more effective and comfortable journey. The study's findings underscore the importance of [considering systemic therapies] for [severe RAS cases] and the potential for [thalidomide] to play a significant role in [managing this condition].

Dr.Camel's Conclusion

This study reminds us that even in the challenging desert of RAS, there may be hidden oases of relief waiting to be discovered. Thalidomide offers a promising path to symptom management for many patients, providing a more comfortable journey through this difficult terrain.

Date :
  1. Date Completed 2010-02-09
  2. Date Revised 2022-06-29
Further Info :

Pubmed ID

19330244

DOI: Digital Object Identifier

PMC2666466

Related Literature

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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