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Pharmacokinetics and behavioral effects of an extended-release, liposome-encapsulated preparation of oxymorphone in rhesus macaques.

Author: BrownCarolyn, HeathTimothy D, Krugner-HigbyLisa, KuKanichButch, SchmidtBrynn, SmithLesley J

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Overview

Liposome-encapsulated oxymorphone (LE-ASG oxy) was found to have a significantly longer duration of action than conventional oxymorphone in rhesus monkeys. LE-ASG oxy was present in serum for more than 2 weeks, while conventional oxymorphone was measurable for only up to 4 hours. Although both formulations did not produce sedation, LE-ASG oxy altered behavioral patterns, such as increasing watchfulness and decreasing self-directed behaviors.
Paper Details　
Original Abstract of the Article :
The objectives of the study were to determine the pharmacokinetics of oxymorphone (oxy) and of ammonium sulfate-loaded, liposome-encapsulated oxymorphone (LE-ASG oxy) and to evaluate the behavioral effects of both opioid preparations by using ethographic evaluation specific to rhesus monkeys. Rhesus...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2700165/

データ提供：米国国立医学図書館（NLM）

Investigating the Pharmacokinetics and Behavioral Effects of Liposome-Encapsulated Oxymorphone in Rhesus Macaques

The field of [pharmacokinetics and behavioral effects of opioids] is crucial for understanding the intricate relationship between drug delivery, drug action, and behavioral outcomes. This study employed [ethographic evaluation and pharmacokinetic analysis] to investigate the impact of [an extended-release, liposome-encapsulated preparation of oxymorphone] in rhesus macaques. The authors aimed to determine [the pharmacokinetic profile and behavioral effects] of this novel opioid preparation compared to standard oxymorphone administration. Their findings provide valuable insights into the potential benefits and challenges associated with this novel delivery method.

Liposome-Encapsulated Oxymorphone Offers Extended Duration and Unique Behavioral Effects

The researchers discovered that [LE-ASG oxy] exhibited a significantly [extended duration of action] in serum compared to standard oxymorphone, lasting for over two weeks. Interestingly, they observed [minimal sedation] but notable changes in behavior, including [decreased environmentally directed behaviors, increased watchfulness, decreased self-directed and elimination behaviors, increased nonspecific social contact, and decreased threat behaviors] in monkeys receiving LE-ASG oxy.

Implications for Opioid Therapy and Research

This study offers valuable insights into the potential for [liposome encapsulation] to improve the pharmacokinetic profile and behavioral effects of opioids. These findings could pave the way for [new therapeutic strategies] for managing pain and other conditions. However, further research is needed to fully understand the long-term implications of this novel delivery method, particularly in humans.

Dr. Camel's Conclusion

Imagine a desert caravan carrying precious spices across vast distances. This study explores how a new delivery method, like a durable camel saddle, can extend the journey of an opioid, delivering its effects for a much longer duration. These findings offer exciting prospects for future research and potential therapeutic applications.

Date :
  1. Date Completed 2009-07-27
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19351868

DOI: Digital Object Identifier

PMC2700165

Related Literature

Article Analysis
・Effects of oxymorphone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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