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Allogeneic stem cell transplantation for acute myeloid leukemia in first complete remission: systematic review and meta-analysis of prospective clinical trials.

Author: AntinJoseph H, AppelbaumFrederick R, CutlerCorey, DeAngeloDaniel J, DjulbegovicBenjamin J, DöhnerHartmut, HondaSumihisa, KopeckyKenneth J, KorethJohn, SakamakiHisashi, SchlenkRichard, SierraJorge, SoifferRobert J, StoneRichard M, WadleighMartha

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

The best treatment for people with acute myeloid leukemia (AML) who achieve remission for the first time is unclear. Current recommendations, based on the risk of the disease, suggest that high-dose chemotherapy and a transplant from a matched donor (allogeneic SCT) are beneficial for high-risk AML, but not for low-risk AML. For intermediate-risk AML, allogeneic SCT, using the patient's own stem cells (autologous transplantation), and intensive chemotherapy are considered to be equally effective.
Paper Details　
Original Abstract of the Article :
The optimal treatment of acute myeloid leukemia (AML) in first complete remission (CR1) is uncertain. Current consensus, based on cytogenetic risk, recommends myeloablative allogeneic stem cell transplantation (SCT) for poor-risk but not for good-risk AML. Allogeneic SCT, autologous transplantation,...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19509382

データ提供：米国国立医学図書館（NLM）

Stem Cell Transplantation for Acute Myeloid Leukemia: A Race Against Time

This study focuses on acute myeloid leukemia (AML), a type of blood cancer that requires aggressive treatment. Imagine a camel racing against time to reach a distant oasis, seeking life-sustaining water. This study investigates the role of allogeneic stem cell transplantation in treating AML, specifically in patients who have achieved a complete remission. Researchers conducted a systematic review and meta-analysis of prospective clinical trials to evaluate the effectiveness of allogeneic stem cell transplantation compared to other treatment options. The study provides insights into the potential benefits and risks of this treatment approach, helping healthcare providers make informed decisions about the best course of action for their patients.

A Balancing Act of Hope

This research highlights the importance of carefully considering the potential benefits and risks associated with allogeneic stem cell transplantation for AML. It's a balancing act, like a camel navigating a treacherous desert landscape. This study provides valuable information to help healthcare providers make informed decisions about the best treatment option for their patients, weighing the potential benefits against the risks.

Collaborative Care

This study underscores the importance of collaboration and communication between healthcare providers and patients. It's crucial to have open and honest conversations about treatment options, potential risks, and individual preferences to make informed decisions. Just as a camel needs to rely on its fellow travelers for support and guidance in the desert, patients need to be actively involved in their own care.

Dr. Camel's Conclusion

This study delves into the complex world of AML treatment, exploring the role of allogeneic stem cell transplantation as a potential option for patients who have achieved complete remission. It highlights the importance of carefully weighing the benefits and risks associated with this treatment approach and underscores the need for collaborative care between patients and healthcare providers.
Date :
  1. Date Completed 2009-06-16
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

19509382

DOI: Digital Object Identifier

NIHMS263072

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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