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Halogenation effects of pheniramines on the complexation with beta-cyclodextrin.

Author: WangLi-Fen

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the formation of inclusion complexes between beta-cyclodextrin and three antihistamines: pheniramine, chlorpheniramine, and brompheniramine. The study found that the inclusion complexes were formed and that the binding strength of the complexes was affected by the halogenation of the phenyl ring.
Paper Details　
Original Abstract of the Article :
This study investigated the inclusion complexes of beta-cyclodextrin with pheniramine and its halogenated derivatives chlorpheniramine and brompheniramine both experimentally and theoretically to characterize the effects of a halogenated phenyl ring on the intermolecular interactions. Fourier transf...See full text at original site
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引用元：
https://doi.org/10.1016/j.jpba.2009.05.027

データ提供：米国国立医学図書館（NLM）

Halogenation Effects: Unlocking the Secrets of Drug Interactions

[Drug development] often involves [modifying existing drugs] to improve their [efficacy and safety]. This study investigates the impact of [halogenation] on the [interaction between pheniramines and beta-cyclodextrin], a [commonly used drug delivery system]. The authors used [a combination of experimental and theoretical methods] to analyze the [complex formation] between [pheniramine and its halogenated derivatives] and [beta-cyclodextrin]. The study reveals that [halogenation significantly affects the binding affinity of pheniramines to beta-cyclodextrin], highlighting the importance of [considering the effects of chemical modifications] on [drug interactions].

Halogenation: A Key to Drug Discovery

The study found that [halogenation] can significantly alter the [interaction between drugs and drug delivery systems]. Imagine a camel traveling through a desert – different types of sand can impact the camel’s journey. Similarly, [halogenation] can alter a [drug’s ability to interact with its delivery system].

The Importance of Chemical Modifications

This study emphasizes the importance of [understanding the effects of chemical modifications] on [drug interactions]. It’s a reminder that [even seemingly small changes] can have a significant impact on [the behavior of drugs in the body].

Dr.Camel's Conclusion

This study provides valuable insight into the [impact of halogenation on drug interactions]. It’s a reminder that [research is constantly advancing], and [new discoveries are being made] all the time. The findings suggest that [understanding the effects of chemical modifications] is crucial for [optimizing drug design and delivery].

Date :
  1. Date Completed 2009-11-10
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19540697

DOI: Digital Object Identifier

10.1016/j.jpba.2009.05.027

Related Literature

Article Analysis
・Effects of brompheniramine
SNS
PICO Info
in preparation
Languages

English

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