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Azathioprine induced pancytopenia: a serious complication.

Author: GoelA, GuptaR, HaddaV, PandeyB D

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This case report describes a patient with lupus nephritis who developed severe pancytopenia after treatment with azathioprine. The patient's condition improved after receiving broad-spectrum antibiotics and granulocyte-macrophage colony stimulating factor. This case highlights the importance of frequent monitoring of blood counts in patients taking azathioprine.
Paper Details　
Original Abstract of the Article :
Azathioprine is commonly used for treatment of lupus nephritis. Myelosuppression is known to occur with azathioprine, but severe pancytopenia is uncommon. A 23-year-old man with lupus nephritis was initially treated with intravenous cyclophosphamide pulses and oral prednisolone along with enalapril ...See full text at original site
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引用元：
https://doi.org/10.4103/0022-3859.52849

データ提供：米国国立医学図書館（NLM）

Azathioprine Induced Pancytopenia: A Rare but Serious Complication

This study explores the serious complications that can arise from azathioprine, a commonly used drug in the treatment of lupus nephritis. While myelosuppression (suppression of bone marrow activity) is a known side effect of azathioprine, severe pancytopenia, characterized by a significant decrease in all blood cell types, is uncommon. This case report highlights the importance of careful monitoring and early detection of these potential complications.

The Importance of Vigilance

The study underscores the need for physicians to be vigilant in monitoring patients treated with azathioprine. The risk of severe bone marrow suppression should be considered, especially in situations where thiopurine methyltransferase (TPMT) testing, a genetic test that can predict the risk of azathioprine-induced myelosuppression, is not available. Regular blood count monitoring is crucial to identify early signs of pancytopenia and enable prompt intervention.

Navigating the Risks and Benefits

Azathioprine, like many medications, offers benefits but also comes with potential risks. The findings emphasize the importance of a careful balance between managing the underlying condition and minimizing the risks of complications.

Dr. Camel's Conclusion

Just as a camel must carefully navigate the desert landscape, avoiding treacherous terrain and seeking safe passage, physicians must navigate the delicate balance between treatment benefits and potential risks. This case study serves as a reminder that vigilance and careful monitoring are essential in managing patients treated with azathioprine.
Date :
  1. Date Completed 2009-09-09
  2. Date Revised 2015-12-21
Further Info :

Pubmed ID

19550063

DOI: Digital Object Identifier

10.4103/0022-3859.52849

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SNS
PICO Info
in preparation
Languages

English

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