Paper Details

  1. Home
  2. Paper Details

Comparative efficacy and safety results of two topical combination acne regimens.

Author: KircikLeon H

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared two common acne treatments for moderate to severe facial acne. Both treatments, a combination of benzoyl peroxide 5% and clindamycin 1% gel (BPO/C) plus tretinoin microsphere gel 0.04% (RAM) and a combination of clindamycin phosphate 1.2% and tretinoin 0.025% gel (CPT) plus benzoyl peroxide 5% wash, were safe and effective. However, the BPO/C+RAM combination showed faster improvement in both non-inflamed and inflamed acne lesions compared to CPT+BPO. Both treatments were well-tolerated by patients.
Paper Details　
Original Abstract of the Article :
Combination therapy has become the standard for the management of acne, particularly for moderate-to-severe cases. Among these combinations, those regimens containing benzoyl peroxide (BPO), clindamycin and a retinoid have been used frequently as they address most aspects of acne pathogenesis. This ...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/19588638

データ提供：米国国立医学図書館（NLM）

Combating Acne: A Comparative Study of Topical Regimens

Acne vulgaris is a common skin condition characterized by pimples, blackheads, and whiteheads. Combination therapy, using multiple ingredients to address the various aspects of acne pathogenesis, has become the standard of care for moderate-to-severe acne. This research compares the efficacy and safety of two topical combination regimens for the treatment of moderate-to-severe facial acne vulgaris.

Finding the Right Path Through the Acne Desert

The study compared two topical regimens: a fixed-combination gel containing benzoyl peroxide 5% and clindamycin 1% (BPO/C) plus tretinoin microsphere gel 0.04% (RAM), and a regimen of a fixed-combination gel containing clindamycin phosphate 1.2% and tretinoin 0.025% (CPT) plus a once-daily BPO 5% wash. The results indicate that both regimens were safe and effective, but the BPO/C+RAM regimen demonstrated a more rapid onset of effect against both non-inflammatory and inflammatory lesions compared to the CPT+BPO regimen. Both regimens were well-tolerated.

Navigating the Desert of Acne: Choosing the Right Treatment

Finding the right acne treatment can feel like navigating a vast and confusing desert. This research provides valuable information for patients and dermatologists seeking to effectively combat moderate-to-severe acne. Knowing the relative effectiveness and safety of different treatment options can help guide the selection of the best path to clear skin.

Dr. Camel's Conclusion

Acne is a common skin condition that can have a significant impact on self-esteem and quality of life. This research sheds light on two effective topical combination regimens for treating acne. It's like choosing the right camel for a desert journey. Each regimen has its own strengths and weaknesses, and careful consideration should be given to finding the best fit for individual needs.
Date :
  1. Date Completed 2009-07-28
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

19588638

DOI: Digital Object Identifier

19588638

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.