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The importance of surgery as the first step in multimodality treatment of small cell bronchial carcinoma. The ISC Lung Cancer Study Group.

Author: ChenD, DenckH, DringsP, HrabarB, Karnicka-MlodkowskaH, KarrerK, LiaoM L, SalzerG M, SunY, ThermannM

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study examined the effectiveness of surgery followed by chemotherapy and radiation therapy for early-stage small cell lung cancer. The study found that patients with stage I cancer had a 4-year survival rate of 61%, while those with stage II cancer had a 4-year survival rate of 35%. The study suggests that surgery is an effective treatment option for stages I and II, and may be beneficial for some patients with stage III cancer. Further research is needed to confirm these findings.
Paper Details　
Original Abstract of the Article :
For patients with small cell lung cancer (SCLC) in their early stages (TNM I, II), surgery for cure was used to eliminate the primary tumour and its regional lymph-nodes followed by intermittent chemotherapy and radiotherapy within the first six postoperative months. After the pathohistological exam...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/1964153

データ提供：米国国立医学図書館（NLM）

Surgery in the Multimodality Treatment of Small Cell Lung Cancer: A Strategic Approach in the Desert of Cancer

The fight against cancer is a continuous journey, and researchers are constantly seeking new strategies to effectively target this formidable adversary. This study examines the role of surgery in the multimodality treatment of small cell lung cancer (SCLC), focusing on patients in their early stages. The study employed a two-arm randomization to compare the effectiveness of standard chemotherapy with sequential chemotherapy, followed by prophylactic cranial irradiation (PCI) for disease-free patients.

Surgery Offers a Promising Starting Point

The study highlights the potential of surgery as the initial step in the multimodality treatment of early-stage SCLC, potentially improving long-term survival rates. The researchers found that the survival rates for patients with SCLC at stages I and II were significantly higher in the surgical group compared to those treated with chemotherapy or radiotherapy alone.

Navigating the Complexities of Cancer Treatment

This study underscores the importance of a multidisciplinary approach to cancer treatment, tailored to the individual needs of each patient. The researchers' emphasis on surgery followed by a combination of chemotherapy and radiotherapy highlights the need for a strategic approach, balancing different treatment modalities to maximize effectiveness.

Dr.Camel's Conclusion

This study provides valuable insights into the role of surgery in the multimodality treatment of early-stage small cell lung cancer. The researchers' findings suggest that surgery can be a promising starting point in the fight against this aggressive cancer, potentially improving survival rates and overall outcomes. As a researcher, I'm continually impressed by the innovative approaches being developed to combat cancer, and I'm optimistic about the future of cancer treatment.
Date :
  1. Date Completed 1991-05-02
  2. Date Revised 2006-04-24
Further Info :

Pubmed ID

1964153

DOI: Digital Object Identifier

1964153

Related Literature

Article Analysis
・Effective treatment of lung cancer
SNS
PICO Info
in preparation
Languages

English

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