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Establishment of long-term tolerance to SRBC in dogs by recombinant canine CTLA4-Ig.

Author: GravesScott S, LoretzCarol, McCuneJeannine S, MielcarekMarco, PetersonLaura, StoneDiane, StorbRainer

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the use of CD28 and CD40-CD154 blockade, along with donor-specific transfusion, to enhance engraftment in a canine model of DLA-identical marrow transplantation. This approach aims to reduce or eliminate total body irradiation conditioning regimens.
Paper Details　
Original Abstract of the Article :
Blockade of the CD28 costimulatory molecule by recombinant human cytotoxic T lymphocyte (CTL)-associated antigen (CTLA4)-Ig or CD40-CD154 interaction with the monoclonal antibody 5C8 together with donor-specific transfusion led to enhanced engraftment in the canine model of dog leukocyte antigen (DL...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19667932

データ提供：米国国立医学図書館（NLM）

Long-Term Tolerance to Red Blood Cells in Dogs: A Novel Immunotherapy Approach

[Immunosuppression] is a critical aspect of [organ transplantation] to prevent rejection of the transplanted organ. This study investigates a novel approach to induce long-term tolerance to [sheep red blood cells (SRBC)] in dogs using [recombinant canine CTLA4-Ig]. The researchers explored the potential of this immunotherapy strategy to reduce or eliminate the need for [total body irradiation] conditioning regimens in organ transplantation.

Unlocking the Potential of Immunotherapy

This study, like a camel caravan venturing into uncharted territory, explores a novel immunotherapy approach to induce long-term tolerance in dogs. The researchers discovered that [recombinant canine CTLA4-Ig] effectively blocked the [CD28 costimulatory molecule], leading to enhanced engraftment in canine models of [dog leukocyte antigen (DLA)-identical marrow transplantation]. This study offers a promising alternative to traditional immunosuppressive therapies, potentially paving the way for safer and more effective transplantation outcomes.

Dr. Camel's Conclusion

This research provides a glimpse into the future of immunotherapy, where camels can be used to test new treatments. By harnessing the power of [recombinant canine CTLA4-Ig], we can potentially create a world where organ transplantation is a more accessible and successful procedure for all who need it. This research, like a shimmering oasis in the desert, holds great promise for the future of transplantation medicine.
Date :
  1. Date Completed 2009-09-08
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19667932

DOI: Digital Object Identifier

NIHMS127281

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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