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Natural compounds endowed with cholinergic or anticholinergic activity. Enhancement of acetylcholine release by a quaternary derivative of L-hyoscyamine.

Author: LapaAntonio José, Lima-LandmanMaria Teresa R, SalamancaAna Lucia V, SouccarCaden, TanaeMirtes M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study re-examined the mechanisms underlying the facilitatory actions of phenthonium (Phen), a quaternary derivative of l-hyoscyamine, on acetylcholine (ACh) release in isolated ganglia of the guinea pig ileal myenteric plexus. The results indicate that Phen's facilitatory action may be mediated by an increase in inwardly rectifying potassium channel conductance, potentially related to its antimuscarinic activity.
Paper Details　
Original Abstract of the Article :
New compounds that target nicotinic receptors (nAChRs) have been sought to correct disorders affecting cholinergic transmission in central and peripheral synapses. A quaternary derivate of l-hyoscyamine, phenthonium (Phen), was shown by our group to enhance the spontaneous acetylcholine (ACh) releas...See full text at original site
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引用元：
https://doi.org/10.1007/s12031-009-9228-1

データ提供：米国国立医学図書館（NLM）

Natural Compounds and Cholinergic Activity: Unlocking the Secrets of the Nervous System

The nervous system, like a vast desert network of hidden pathways, holds countless secrets. This study delves into the fascinating world of natural compounds that influence cholinergic activity, the communication system of the nervous system. The authors explore the mechanisms of action of a specific compound, phenthonium, and its potential to enhance acetylcholine release.

Unveiling the Mechanism

The study revealed that phenthonium, like a skilled desert guide, can enhance acetylcholine release without affecting nerve-induced transmission. The researchers uncovered its unique ability to act on potassium channels, offering valuable insights into the complex workings of the nervous system.

A Promise for the Future

This study provides a foundation for further research into the potential therapeutic applications of phenthonium and other natural compounds that modulate cholinergic activity. It's like discovering a hidden oasis of potential treatments, offering hope for addressing neurological disorders.

Dr.Camel's Conclusion

The world of natural compounds holds immense potential for understanding and treating neurological disorders. This research is a testament to the ongoing exploration of these natural treasures, revealing hidden pathways and mechanisms that could lead to new therapies and a better understanding of the complex desert of the human nervous system.

Date :
  1. Date Completed 2010-04-21
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

19688610

DOI: Digital Object Identifier

10.1007/s12031-009-9228-1

Related Literature

Article Analysis
・Effects of hyoscyamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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