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Diacetylmorphine versus methadone for the treatment of opioid addiction.

Author: AnisAslam, BrissetteSuzanne, GuhDaphne, LauzonPierre, MarshDavid C, Oviedo-JoekesEugenia, SchechterMartin T

Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Injectable diacetylmorphine was more effective than oral methadone for opioid dependence that was refractory to treatment. However, there was a risk of overdoses and seizures, so diacetylmorphine maintenance therapy should be delivered in settings where prompt medical intervention is available.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Studies in Europe have suggested that injectable diacetylmorphine, the active ingredient in heroin, can be an effective adjunctive treatment for chronic, relapsing opioid dependence. METHODS: In an open-label, phase 3, randomized, controlled trial in Canada, we compared injectable diace...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/19692689

データ提供：米国国立医学図書館（NLM）

A New Path for Opioid Addiction: Comparing Diacetylmorphine and Methadone

The struggle against opioid addiction is a constant challenge, requiring innovative treatment approaches. This research compares the effectiveness of injectable diacetylmorphine (heroin) and oral methadone maintenance therapy for opioid dependence. The study examines the effectiveness of these treatments by analyzing retention in addiction treatment, illicit drug use, and other illegal activities.

Diacetylmorphine Emerges as a Promising Alternative

The study found that injectable diacetylmorphine was significantly more effective than oral methadone in retaining patients in addiction treatment, reducing illicit drug use, and decreasing involvement in other illegal activities. This suggests that diacetylmorphine, despite its potential risks, may offer a valuable alternative treatment option for opioid dependence.

Harnessing the Potential of Diacetylmorphine: A Cautious Approach

This research underscores the need for careful consideration of the risks and benefits of diacetylmorphine maintenance therapy. While the study demonstrates its potential effectiveness, it also acknowledges the risk of overdoses and seizures, emphasizing the importance of strict medical supervision in settings where prompt medical intervention is readily available. This research provides valuable insight into the complex world of opioid addiction treatment and highlights the importance of informed decision-making and appropriate medical oversight.

Dr. Camel's Conclusion

Imagine a weary traveler in the desert, seeking respite from the harsh conditions. This research explores the potential of diacetylmorphine as a treatment for opioid dependence, much like a refreshing oasis offering relief for a thirsty traveler. While diacetylmorphine has shown promise in this study, it's important to proceed with caution, just as a traveler approaching an oasis needs to be aware of potential dangers. This research sheds light on the complexities of addiction treatment and emphasizes the need for careful consideration of all treatment options and their associated risks and benefits.

Date :
  1. Date Completed 2009-08-27
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

19692689

DOI: Digital Object Identifier

CAMS373

Related Literature

Article Analysis
・Effective treatment of heroin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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