Polymorphisms of human cytochrome P450 2C9 and the functional relevance.

Author: HuangMin, ZhouShu-Feng, ZhouZhi-Wei

Paper Details 
Original Abstract of the Article :
Human cytochrome P450 2C9 (CYP2C9) accounts for ∼20% of hepatic total CYP content and metabolizes ~15% clinical drugs such as phenytoin, S-warfarin, tolbutamide, losartan, and many nonsteroidal anti-inflammatory agents (NSAIDs). CYP2C9 is highly polymorphic, with at least 33 variants of CYP2C9 (*1B ...See full text at original site
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引用元:
https://doi.org/10.1016/j.tox.2009.08.013

データ提供:米国国立医学図書館(NLM)

The Intricacies of CYP2C9: A Key Player in Drug Metabolism

CYP2C9 is an important enzyme in the body, responsible for breaking down many common medications. This study, like a chemist carefully analyzing a complex compound, explores the genetic variations in CYP2C9 and their impact on drug metabolism and response. It's a fascinating glimpse into the intricate world of pharmacogenetics, where our genes can influence how our bodies react to medications.

CYP2C9 Polymorphisms: A Shifting Landscape of Drug Metabolism

The study reveals that variations in the CYP2C9 gene can significantly alter the way our bodies process certain medications, like the different ways a desert landscape might respond to rainfall. This knowledge can be crucial for tailoring drug therapy to individual patients, ensuring optimal effectiveness and minimizing potential side effects.

Personalized Medicine: Navigating the Desert of Individuality

This research highlights the importance of personalized medicine, where treatment is tailored to the unique genetic makeup of each individual. It emphasizes the need for further research and genetic testing to optimize drug therapy and enhance patient outcomes. Just as a skilled desert guide adjusts the caravan's route based on the terrain and weather conditions, we must learn to adapt our treatment strategies based on each individual's genetic profile.

Dr. Camel's Conclusion

This study, like a desert oasis offering refreshing knowledge, reveals the intricate interplay between our genes and the way our bodies respond to medications. It underscores the importance of understanding individual variations in CYP2C9, paving the way for more precise and effective drug therapy. By embracing personalized medicine, we can navigate the complex landscape of drug interactions with greater care and precision, ensuring optimal health outcomes for each individual.
Date :
  1. Date Completed 2010-12-08
  2. Date Revised 2014-11-20
Further Info :

Pubmed ID

19715737

DOI: Digital Object Identifier

10.1016/j.tox.2009.08.013

SNS
PICO Info
in preparation
Languages

English

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