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Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease.

Author: ClarkeCarl E, GrossetDonald, StewartDavid, WorthPaul

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

While oral levodopa is used for Parkinson's disease, its short duration of action leads to fluctuating symptoms and movement problems. Other treatments aim to provide a more consistent effect, but some patients with advanced disease don't respond. This review examined the effectiveness of three treatments for advanced Parkinson's disease: levodopa infusions, intraduodenal levodopa, and deep brain stimulation (DBS). All three treatments showed benefits in reducing symptoms and improving daily living activities compared to standard medication. However, information on side effects was limited, and there is a need for more research comparing these treatments directly. For now, treatment decisions are based on clinical judgment and patient preference.
Paper Details　
Original Abstract of the Article :
The effectiveness of oral levodopa in complex Parkinson's disease (PD) is limited by its short half-life, and the resulting pulsatile dopaminergic stimulation leads to complex motor fluctuations and dyskinesia. Several treatments provide more continuous/less pulsatile dopaminergic stimulation by mod...See full text at original site
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引用元：
https://doi.org/10.1016/j.parkreldis.2009.09.005

データ提供：米国国立医学図書館（NLM）

Systematic review of apomorphine infusion, levodopa infusion and deep brain stimulation in advanced Parkinson's disease

Parkinson's disease, a debilitating neurological condition, often presents challenges in managing its advanced stages. This systematic review explores the effectiveness of three treatment modalities: apomorphine infusion, levodopa infusion, and deep brain stimulation (DBS), in providing continuous dopaminergic stimulation for individuals with advanced Parkinson's disease. The authors found that all three therapies showed significant improvements in the proportion of the waking day in a functional 'on' state, activities of daily living, and motor score, compared to standard medical management. The study also highlights the need for more robust clinical trials to provide definitive evidence for the best treatment approach.

Finding the oasis in the desert of Parkinson's disease

This review underscores the importance of continuous dopaminergic stimulation in managing advanced Parkinson's disease. While the therapies reviewed demonstrated potential benefits, the lack of direct comparative data necessitates a cautious approach. As a wise camel, I understand the importance of finding the right oasis to quench your thirst. In this case, finding the most effective and safe treatment for advanced Parkinson's disease requires careful consideration of individual needs and preferences.

Navigating the path to a better quality of life

The findings suggest that apomorphine infusion, levodopa infusion, and DBS hold promise for improving the quality of life for individuals with advanced Parkinson's disease. It is essential to consult with your doctor to determine the most appropriate treatment plan, taking into account individual needs and potential risks and benefits. Open communication and careful monitoring are crucial in managing this complex condition.

Dr.Camel's Conclusion

This systematic review highlights the potential benefits of apomorphine infusion, levodopa infusion, and DBS in managing advanced Parkinson's disease. However, more research is needed to establish definitive evidence for the best treatment approach. The authors rightly emphasize the need for well-designed clinical trials to inform clinical management for this challenging subgroup of patients.

Date :
  1. Date Completed 2010-01-27
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

19805000

DOI: Digital Object Identifier

10.1016/j.parkreldis.2009.09.005

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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