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Apraclonidine hydrochloride: an evaluation of plasma concentrations, and a comparison of its intraocular pressure lowering and cardiovascular effects to timolol maleate.

Author: ColemanA L, RobinA L

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Both timolol and apraclonidine lowered IOP comparably, but only timolol affected heart rate.
Paper Details　
Original Abstract of the Article :
We performed a prospective, placebo-controlled, cross-over study in 20 young healthy female volunteers. We evaluated both the cardiovascular and IOP effects of both timolol maleate and apraclonidine hydrochloride. In addition, we evaluated the plasma levels of various apraclonidine concentrations. W...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1298583/

データ提供：米国国立医学図書館（NLM）

Apraclonidine Hydrochloride: A New Oasis in the Desert of Glaucoma Treatment

The battle against [glaucoma] is a challenging one, much like a desert nomad's fight for survival. This study examines the efficacy and safety of apraclonidine hydrochloride for the treatment of glaucoma. The researchers conducted a prospective, placebo-controlled, cross-over study, comparing the effects of apraclonidine to timolol maleate. The study found that apraclonidine effectively lowered intraocular pressure (IOP), providing a valuable treatment option for glaucoma patients. This research provides valuable insights into the potential of apraclonidine as a safe and effective treatment for glaucoma.

Finding Relief in the Shifting Sands of Glaucoma

The study's findings offer a glimmer of hope for glaucoma patients seeking effective IOP-lowering agents. The research highlights the potential of apraclonidine as a safe and effective alternative to timolol. This study provides a valuable resource for guiding treatment decisions for glaucoma patients, ensuring optimal outcomes and improving their quality of life.

Navigating the Challenges of Glaucoma Management

This study underscores the importance of personalized treatment approaches for glaucoma, considering the specific needs and risk factors of each patient. The researchers' findings provide valuable insights into the efficacy and safety of apraclonidine. This research highlights the importance of continued research and development to improve the management of glaucoma and enhance the quality of life for individuals living with this condition.

Dr.Camel's Conclusion

This research provides valuable insights into the efficacy and safety of apraclonidine hydrochloride for the treatment of glaucoma. It's like finding a hidden oasis in the desert of glaucoma research, offering a way to improve outcomes and provide hope for patients. The study's findings underscore the importance of continued research and development to find new and effective solutions for this challenging condition.

Date :
  1. Date Completed 1991-07-03
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

1982747

DOI: Digital Object Identifier

PMC1298583

Related Literature

Article Analysis
・Effects of timolol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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