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Bifidobacterium as an oral delivery carrier of oxyntomodulin for obesity therapy: inhibitory effects on food intake and body weight in overweight mice.
Author: ChenL Y, GuoJ, HuangQ S, LinY Z, LongR T, LuoS Q, ZengW S
Original Abstract of the Article :
Oxyntomodulin (OXM) is a gut hormone released from intestinal L cell. Synthetic OXM and its analog reduce food intake and body weight in both rodents and human beings by being administered intravenously. However, people find intravenous administration difficult because of its side effects and inconv...See full text at original site
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引用元:
https://doi.org/10.1038/ijo.2009.277
データ提供:米国国立医学図書館(NLM)
A Novel Approach to Obesity Treatment: Bifidobacterium as a Delivery System for Oxyntomodulin
The field of obesity research is constantly evolving, with scientists seeking novel approaches to combat this growing global health concern. This particular study delves into the potential of utilizing a specific type of bacteria, Bifidobacterium, as a delivery system for the gut hormone oxyntomodulin (OXM). This approach aims to address the challenges associated with conventional intravenous administration of OXM, which often leads to side effects and inconvenience for patients. The researchers engineered Bifidobacterium to act as a carrier for OXM, paving the way for a potentially more efficient and tolerable oral delivery method.
Oral Delivery of Oxyntomodulin: A Promising Strategy for Obesity Management
The findings of this study suggest that utilizing Bifidobacterium as an oral delivery system for OXM could be a viable strategy for managing obesity. This method holds the potential to overcome the limitations of intravenous administration, offering a more convenient and potentially safer treatment option for individuals struggling with weight management. The study observed significant reductions in food intake and body weight in overweight mice, demonstrating the efficacy of this novel approach.
Potential Benefits for Weight Management and Beyond
The successful implementation of this research could lead to the development of a new generation of weight management therapies that are both effective and well-tolerated by patients. The use of Bifidobacterium as a delivery system opens up a new avenue for targeted drug delivery and could have implications for the treatment of other conditions beyond obesity.
Dr.Camel's Conclusion
This research on using Bifidobacterium as an oral delivery carrier for oxyntomodulin presents a promising approach to obesity therapy. It is like finding a new oasis in the vast desert of weight management solutions. The potential benefits of this approach are vast, including improved patient compliance, fewer side effects, and ultimately, a more effective way to manage obesity. This research has the potential to make a significant contribution to the fight against this global health challenge.
Date :
- Date Completed 2010-10-27
- Date Revised 2018-12-01
Further Info :
Related Literature
English
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