Paper Details

  1. Home
  2. Paper Details

Long-term antibiotic treatment for Crohn's disease: systematic review and meta-analysis of placebo-controlled trials.

Author: EggerMatthias, FellerMartin, FurrerHansjakob, HuwilerKarin, SchoepferAlain, ShangAijing

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Long-term treatment with nitroimidazoles or clofazimine appears to be effective in patients with Crohn's disease. The study found that both drug classes were associated with significant improvements in remission rates and reduced relapse rates.
Paper Details　
Original Abstract of the Article :
BACKGROUND: We investigated the effectiveness of long-term antibiotic treatment in patients with Crohn's disease. METHODS: We performed a systematic review and meta-analysis of randomized clinical trials. Data sources were Medline (from 1966 through June 2009), EMBASE (from 1980 through June 2009),...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1086/649923

データ提供：米国国立医学図書館（NLM）

The Role of Long-Term Antibiotics in Crohn's Disease Management

This study delves into the effectiveness of long-term antibiotic therapy in patients with Crohn's disease, a chronic inflammatory bowel disorder. The authors conducted a systematic review and meta-analysis of randomized clinical trials, examining the use of various antibiotic regimens. Their analysis revealed that long-term treatment with nitroimidazoles or clofazimine was associated with a significant benefit in terms of achieving remission and preventing relapse. However, the study also indicated no benefit from classic drugs against tuberculosis or clarithromycin. These findings contribute to the growing understanding of the potential role of antibiotics in managing Crohn's disease.

Unlocking the Potential of Antibiotics for Crohn's Disease

The study highlights the potential of certain antibiotics, particularly nitroimidazoles and clofazimine, to improve outcomes for patients with Crohn's disease. The findings suggest that these medications may be valuable tools in the management of this chronic condition. The research also emphasizes the need for further studies to explore the mechanisms of action and optimal use of these antibiotics in Crohn's disease management.

Navigating the Landscape of Crohn's Disease Treatment

Crohn's disease presents a unique set of challenges for patients and healthcare professionals. This study underscores the need for a personalized approach to treatment, taking into account individual patient characteristics and disease severity. The findings highlight the importance of ongoing research to develop new and improved therapies for this chronic condition. With continued investigation, we can hope to discover new approaches that may offer relief and improved quality of life for individuals living with Crohn's disease.

Dr. Camel's Conclusion

This study is like a camel caravan traversing the vast and complex landscape of Crohn's disease. It uncovers the potential of specific antibiotics to bring relief to those affected by this chronic condition. The journey to find effective therapies for Crohn's disease is as challenging as a desert trek, requiring perseverance and a commitment to improving the lives of those living with this debilitating disorder.

Date :
  1. Date Completed 2010-04-21
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20067425

DOI: Digital Object Identifier

10.1086/649923

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.