Safety and tolerability of rivastigmine transdermal patch compared with rivastigmine capsules in patients switched from donepezil: data from three clinical trials.

Author: FarlowM R, MengX, OlinJ T, SadowskyC H

Paper Details 
Original Abstract of the Article :
OBJECTIVES: To compare the safety and tolerability of switching patients with mild-to-moderate Alzheimer's disease from donepezil to either rivastigmine capsule or transdermal patch. METHODS: Three studies investigated the switch from donepezil to rivastigmine; study US13 was a 26-week, single-arm,...See full text at original site
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引用元:
https://doi.org/10.1111/j.1742-1241.2009.02253.x

データ提供:米国国立医学図書館(NLM)

Rivastigmine for Alzheimer's Disease: Comparing Transdermal Patch and Capsules

This research compares the safety and tolerability of switching patients with mild-to-moderate Alzheimer's disease from donepezil to either rivastigmine capsules or a transdermal patch. The study analyzed data from three clinical trials, examining the occurrence of adverse events (AEs), discontinuations due to AEs, and serious AEs (SAEs). The authors found that the rivastigmine transdermal patch demonstrated better tolerability than capsules, with fewer gastrointestinal AEs and discontinuations. The research suggests that the transdermal patch may offer a more convenient and tolerable treatment option for patients with Alzheimer's disease.

Finding the Right Fit for Alzheimer's Treatment: Comparing Delivery Methods

This study provides valuable insights into the safety and tolerability of rivastigmine, a medication used to treat Alzheimer's disease. The research found that the transdermal patch demonstrated better tolerability compared to capsules, with fewer gastrointestinal AEs and discontinuations. This study emphasizes the importance of considering different delivery methods and individualizing treatment approaches based on patient preferences and tolerance. By exploring alternative delivery options, we can improve the quality of life for patients with Alzheimer's disease and enhance their overall well-being.

Navigating Alzheimer's Treatment: Tailoring Approaches for Optimal Results

This research highlights the importance of considering different delivery methods for Alzheimer's medications. The study found that the rivastigmine transdermal patch demonstrated better tolerability than capsules, with fewer gastrointestinal AEs and discontinuations. This underscores the importance of individualizing treatment approaches based on patient preferences and tolerance to ensure optimal results. By providing patients with a range of options and tailoring treatment plans accordingly, we can enhance their treatment experience and improve their overall well-being.

Dr. Camel's Conclusion

This research provides valuable insights into the safety and tolerability of rivastigmine for Alzheimer's disease. The study highlights the benefits of the transdermal patch, offering a more convenient and tolerable treatment option. Just like finding a cool and refreshing oasis in a hot desert, finding the right delivery method for Alzheimer's medications can significantly improve patient outcomes and enhance their quality of life.

Date :
  1. Date Completed 2011-03-24
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20089009

DOI: Digital Object Identifier

10.1111/j.1742-1241.2009.02253.x

Related Literature

SNS
PICO Info
in preparation
Languages

English

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