Paper Details

  1. Home
  2. Paper Details

Effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole treatments during acute infection of two different Trypanosoma cruzi strains.

Author: AlbuquerqueSérgio, KuehnChristian Collins, LoriaRoger M, OliveiraLuiz Gustavo Rodrigues, SantosCarla Domingues, ToldoMíriam Paula Alonso, do PradoJosé Clóvis

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the effect of dehydroepiandrosterone-sulfate ester (DHEA-S) therapy alone or in combination with benznidazole (BNZ) in the treatment of Trypanosoma cruzi infection in rats. DHEA-S therapy was effective in reducing parasite load and improving survival rates in infected rats, suggesting its potential as a therapeutic agent against Chagas disease.
Paper Details　
Original Abstract of the Article :
A significant role for hormones in regulating the balance of Th1- and Th2-associated cytokines with a role in modulating diseases has been accumulating. Previously, we reported that dehydroepiandrosterone (DHEA), the most abundant steroid hormone synthesized by the adrenal cortex, markedly reduced t...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.imbio.2009.11.002

データ提供：米国国立医学図書館（NLM）

DHEA-S and Benznidazole: A Combined Approach to Combat Trypanosoma cruzi

The field of parasitology is constantly searching for effective treatments for debilitating parasitic diseases. This research investigates the potential therapeutic effects of dehydroepiandrosterone-sulfate (DHEA-S) and benznidazole (BNZ), two medications commonly used to treat Chagas disease, caused by the parasite Trypanosoma cruzi.

Imagine the body as a vast desert, vulnerable to invasion by parasitic organisms. Trypanosoma cruzi, like a persistent desert creature, can cause significant health problems. This research investigates the effectiveness of DHEA-S and BNZ, like powerful antidotes, in combating this parasitic threat.

Combating Trypanosoma cruzi: A Synergistic Approach

The study examined the effects of DHEA-S and BNZ, both alone and in combination, on two different strains of Trypanosoma cruzi. The results showed that both DHEA-S and BNZ were effective in reducing parasite load. Furthermore, DHEA-S treatment alone led to complete clearance of the Bolivia strain of T. cruzi. This suggests that DHEA-S may have potential as a treatment option for Chagas disease.

A New Frontier in Chagas Disease Treatment

These findings highlight the potential of DHEA-S as a therapeutic agent for Chagas disease. The study suggests that combining DHEA-S with conventional treatments like BNZ may enhance treatment efficacy and potentially reduce mortality. It's like discovering a new oasis in the desert of Chagas disease research, offering hope for improved treatment options.

Dr. Camel's Conclusion

This study suggests that DHEA-S may have therapeutic potential for Chagas disease, offering a promising new avenue for treatment. The research encourages further investigation into the role of DHEA-S in combating Trypanosoma cruzi infection. It's a reminder that exploration and innovation are essential in the field of parasitology, leading to new discoveries and advancements in patient care.

Date :
  1. Date Completed 2011-03-08
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

20163889

DOI: Digital Object Identifier

10.1016/j.imbio.2009.11.002

Related Literature

Article Analysis
・Effects of benznidazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.