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Synergistic anti-Pneumocystis carinii effects of erythromycin and sulfisoxazole.

Author: HughesW T, KillmarJ T

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

Erythromycin and sulfisoxazole effectively prevented and treated Pneumocystis carinii pneumonitis in immunosuppressed rats, suggesting its potential use in AIDS patients.
Paper Details　
Original Abstract of the Article :
Pneumocystis carinii pneumonitis was effectively prevented in 90% of immunosuppressed rats by the administration of 100 mg of erythromycin and 300 mg/kg/day of sulfisoxazole. All of the untreated control and erythromycin-treated animals developed the infection and 80% of rats given sulfisoxazole alo...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2016690

データ提供：米国国立医学図書館（NLM）

Fighting Pneumocystis Carinii: A Synergistic Approach

Pneumocystis carinii pneumonia (PCP) is a serious lung infection that can be life-threatening, particularly in immunocompromised individuals. This research, published in the Journal of Infectious Diseases, investigates the synergistic effects of erythromycin and sulfisoxazole in preventing and treating PCP in rats. The study found that the combination of erythromycin and sulfisoxazole was more effective in both preventing and treating PCP than either drug alone. The authors suggest that this drug combination, with a proven safety record, warrants further investigation for treating PCP in AIDS patients.

A Powerful Partnership: Combining Forces Against PCP

This research highlights the potential benefits of combining erythromycin and sulfisoxazole for managing PCP, suggesting that this synergistic approach may offer improved efficacy. The authors' call for further investigation in AIDS patients underscores the need for continued research and exploration of new treatment options for this challenging infection.

Oasis in the Desert of Infection: Finding a New Treatment

This study offers hope for patients with PCP by suggesting that the combination of erythromycin and sulfisoxazole may provide a more effective treatment option. Further research is needed to confirm these findings, but this study provides a valuable starting point for exploring new ways to combat this serious infection.

Dr. Camel's Conclusion

PCP can feel like a relentless sandstorm, but this research offers a glimmer of hope in the form of a synergistic approach. The combination of erythromycin and sulfisoxazole may offer a powerful weapon against this infection, providing a potential oasis in the desert of illness.
Date :
  1. Date Completed 1991-05-20
  2. Date Revised 2020-02-20
Further Info :

Pubmed ID

2016690

DOI: Digital Object Identifier

2016690

Related Literature

Article Analysis
・Effects of erythromycin and sulfisoxazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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