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Effect of oral antihistamine on local injection site reactions with self-administered glatiramer acetate.

Author: BoutwellChristine, ConnerJill, DenneyDouglas, Oleen-BurkeyMerriKay, PardoGabriel

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study evaluated the efficacy of cetirizine, an oral antihistamine, in reducing local injection site reactions (LISRs) associated with glatiramer acetate therapy for multiple sclerosis. While cetirizine slightly decreased the number of LISRs, the difference was not statistically significant. Both groups showed a significant reduction in mean LISR score during the treatment period.
Paper Details　
Original Abstract of the Article :
Patients with multiple sclerosis often use injectable medication such as glatiramer acetate or interferons to treat their disease. Subcutaneous injections may be associated with local injection site reactions (LISRs), which can include itching, pain, swelling, or redness. Although not serious, these...See full text at original site
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引用元：
https://doi.org/10.1097/jnn.0b013e3181c71ab7

データ提供：米国国立医学図書館（NLM）

Oral Antihistamine: A Solution for Glatiramer Acetate Injection Site Reactions?

This study explores the [impact of oral antihistamines on injection site reactions (LISRs)] associated with glatiramer acetate therapy, a journey through the intricate landscape of [multiple sclerosis (MS) treatment]. The research, like a diligent scientist carefully analyzing sand samples, investigates whether [pre-treatment with cetirizine hydrochloride] can reduce the incidence of LISRs in patients receiving glatiramer acetate. The results, however, do not provide conclusive evidence that [cetirizine significantly reduces LISRs] in this context.

Oral Antihistamines: A Potential but Unproven Solution for Glatiramer Acetate LISRs

This study, like a mirage in the desert, suggests that oral antihistamines may not be the definitive solution for reducing LISRs associated with glatiramer acetate. While the findings do not show a significant reduction in LISRs with cetirizine, the study does highlight the need for [further research and exploration of alternative strategies] to alleviate this common side effect of glatiramer acetate therapy.

Managing Glatiramer Acetate LISRs: A Continued Quest

The study highlights the ongoing challenge of [managing LISRs] in patients receiving glatiramer acetate. While this study did not demonstrate a significant benefit from using oral antihistamines, the research underscores the importance of [exploring other potential solutions] and continuing to investigate ways to improve the patient experience with this therapy.

Dr. Camel's Conclusion

This research, like a camel caravan searching for a hidden oasis, explores the potential of oral antihistamines in reducing LISRs associated with glatiramer acetate therapy. The findings do not provide conclusive evidence to support the use of cetirizine for this purpose, indicating the need for continued research and exploration of alternative strategies.
Date :
  1. Date Completed 2010-03-26
  2. Date Revised 2019-10-27
Further Info :

Pubmed ID

20187348

DOI: Digital Object Identifier

10.1097/jnn.0b013e3181c71ab7

Related Literature

Article Analysis
・Side Effects of cetirizine injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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