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Cevimeline enhances the excitability of rat superior salivatory neurons.

Author: IchikawaHiroyuki, KobashiMotoi, MatsuoRyuji, MitohYoshihiro, UedaHirotaka, YamashiroTakashi

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Cevimeline is a drug that stimulates salivary glands and may have effects on the central nervous system. This study found that cevimeline increases the excitability of superior salivatory neurons, which control submandibular salivation, by activating both pre- and postsynaptic muscarinic receptors.
Paper Details　
Original Abstract of the Article :
Cevimeline, a therapeutic drug for xerostomia, is an agonist of muscarinic acetylcholine receptors (mAChRs), and directly stimulates the peripheral mAChRs of the salivary glands. Since cevimeline is distributed in the brain after its oral administration, it is possible that it affects the central ne...See full text at original site
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引用元：
https://doi.org/10.2152/jmi.56.267

データ提供：米国国立医学図書館（NLM）

Cevimeline: A Promising Drug for Xerostomia

The field of [Pharmacology] is always exploring new treatments for [Xerostomia], a condition that can significantly impact quality of life. This research delves into the effects of [Cevimeline] on [Superior Salivatory Neurons]. The authors used [Whole-Cell Patch-Clamp Technique] to investigate the drug's impact on [Salivary Gland Function]. Their findings suggest that [Cevimeline] acts as an [Agonist] of [Muscarinic Acetylcholine Receptors], enhancing the excitability of [Superior Salivatory Neurons] and potentially stimulating [Salivary Gland Activity]. One of the key takeaways is that [Cevimeline] might offer a promising therapeutic option for individuals experiencing [Xerostomia].

Exploring the Potential of Cevimeline in Xerostomia Treatment

The study highlights [Cevimeline]'s ability to directly stimulate [Salivary Glands], which could be a significant breakthrough in treating [Xerostomia]. The research results suggest that [Cevimeline] acts as an [Agonist], potentially enhancing [Salivary Gland Function] and alleviating the dryness associated with [Xerostomia]. This offers hope for a new therapeutic approach to this debilitating condition.

Cevimeline: A Potential Solution for Dry Mouth?

Living with [Xerostomia] can be challenging, making it difficult to [Engage in Activities] that involve [Oral Function]. This research suggests that [Cevimeline] could help alleviate the discomfort and functional limitations associated with [Dry Mouth]. Remember to consult with your healthcare provider to determine if this drug is right for you.

Dr. Camel's Conclusion

The prospect of a new drug like [Cevimeline] targeting [Xerostomia] is exciting! The research findings offer hope for a better future for individuals suffering from this condition. Think of it like a camel finding a oasis in the desert, providing much-needed relief from dryness. While [Cevimeline] shows promise, further research is essential to fully understand its effectiveness and safety. Consult with a healthcare professional to discuss your treatment options.

Date :
  1. Date Completed 2010-06-21
  2. Date Revised 2019-11-11
Further Info :

Pubmed ID

20224198

DOI: Digital Object Identifier

10.2152/jmi.56.267

Related Literature

Article Analysis
・Effects of cevimeline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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