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Rifamycins--obstacles and opportunities.

Author: AristoffPaul A, GarciaGeorge A, KirchhoffPaul D, ShowalterH D

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Rifamycins, such as rifampin, are important drugs for treating tuberculosis (TB) but have limitations including drug resistance, hepatotoxicity, and drug interactions. This review discusses the potential for developing improved rifamycin analogs.
Paper Details　
Original Abstract of the Article :
With nearly one-third of the global population infected by Mycobacterium tuberculosis, TB remains a major cause of death (1.7 million in 2006). TB is particularly severe in parts of Asia and Africa where it is often present in AIDS patients. Difficulties in treatment are exacerbated by the 6-9 month...See full text at original site
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引用元：
https://doi.org/10.1016/j.tube.2010.02.001

データ提供：米国国立医学図書館（NLM）

Rifamycins: A Journey Through the Desert of Tuberculosis Treatment

This review delves into the complex landscape of rifamycins, a class of antibiotics that have been a mainstay in the treatment of tuberculosis (TB) for decades. The researchers examine the challenges and opportunities presented by rifamycins in the fight against TB, a global health threat affecting millions of people worldwide. They discuss the limitations of rifamycins, including the emergence of drug-resistant strains, potential side effects, and drug-drug interactions. The review also highlights the ongoing efforts to develop improved rifamycin analogs with enhanced efficacy and reduced side effects, offering hope for a more effective and safer treatment for TB. This review is like a guide leading us through the vast desert of TB research, highlighting the challenges and opportunities presented by rifamycins in the fight against this devastating disease.

Rifamycin Analogs: New Weapons in the Fight Against TB

The review highlights the ongoing efforts to develop improved rifamycin analogs, offering hope for a more effective and safer treatment for TB. This research is like a search for new weapons in the fight against TB, exploring potential solutions to overcome the challenges of drug resistance and side effects. The development of more potent and less toxic rifamycin analogs could significantly impact the treatment of TB, offering a brighter future for those affected by this disease.

Navigating the Complexities of TB Treatment

This review underscores the complexity of treating TB and the ongoing need for research into novel therapies. The development of improved rifamycin analogs represents a significant step forward in the fight against TB, offering hope for more effective and safer treatments. The review is a testament to the tireless pursuit of new and improved treatments for TB, a reminder that in the vast desert of this disease, there may be many hidden oases of innovation waiting to be discovered.

Dr.Camel's Conclusion

This review provides a comprehensive overview of the challenges and opportunities presented by rifamycins in the treatment of TB. The research highlights the ongoing efforts to develop improved rifamycin analogs, offering hope for more effective and safer treatments for this global health threat. The findings are like a wellspring of hope in the desert of TB research, offering a potential path towards better treatment options and a brighter future for those affected by this disease.

Date :
  1. Date Completed 2011-11-09
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

20236863

DOI: Digital Object Identifier

10.1016/j.tube.2010.02.001

SNS
PICO Info
in preparation
Languages

English

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