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Sensitivity to triazolam in the elderly.

Author: EngelhardtN, GouthroT A, GreenblattD J, HarmatzJ S, ShaderR I, ShapiroL

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.

Overview

The effect of age on the pharmacokinetics and pharmacodynamics of triazolam, a benzodiazepine hypnotic agent, was investigated.
Paper Details　
Original Abstract of the Article :
Elderly persons frequently appear to be sensitive to the effects of many drugs that depress the central nervous system. We studied the effect of age on the pharmacokinetics and pharmacodynamics of the benzodiazepine hypnotic agent triazolam, now the most frequently prescribed hypnotic drug in the Un...See full text at original site
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引用元：
https://doi.org/10.1056/NEJM199106133242403

データ提供：米国国立医学図書館（NLM）

Triazolam: A Journey Through the Desert of Age

The effects of medications can vary significantly with age. This study explores the effects of age on the pharmacokinetics and pharmacodynamics of triazolam, a commonly prescribed hypnotic drug, in older adults. The researchers found that elderly individuals appear to be more sensitive to the effects of triazolam, underscoring the importance of careful dose adjustments in older patients. This study highlights the need for age-specific considerations when prescribing medications.

A Reminder of the Need for Age-Specific Considerations

This research emphasizes the importance of considering age when prescribing medications, particularly those that affect the central nervous system. Just as a traveler in the desert needs to be mindful of the harsh conditions, healthcare providers need to be aware of the unique challenges and sensitivities associated with aging. Careful dose adjustments and monitoring are crucial in ensuring the safety and efficacy of medications in older adults.

Navigating the Desert of Senescence

The desert of senescence, a journey we all undertake as we age, can present unique challenges. This research highlights the importance of being mindful of how aging affects our responses to medications. Just as a traveler in the desert needs to adapt to the changing environment, healthcare providers need to be aware of the unique needs of older patients and adjust medication regimens accordingly. This research underscores the importance of personalized medicine and the need to tailor treatments to the individual patient.

Dr.Camel's Conclusion

This study provides valuable insights into the effects of aging on the response to medications. It highlights the importance of careful dose adjustments and close monitoring in older adults, reminding us to treat each patient as a unique individual with specific needs. Just as a traveler in the desert must be adaptable and prepared, healthcare providers must be mindful of the challenges and opportunities presented by aging and adjust their approach accordingly.

Date :
  1. Date Completed 1991-06-24
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

2034245

DOI: Digital Object Identifier

10.1056/NEJM199106133242403

Related Literature

Article Analysis
・Effects of triazolam
SNS
PICO Info
in preparation
Languages

English

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