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High rates of sustained virological response in hepatitis C virus-infected injection drug users receiving directly observed therapy with peginterferon alpha-2a (40KD) (PEGASYS) and once-daily ribavirin.

Author: AckermannGrit, WaizmannMichael

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This retrospective study evaluated the efficacy and tolerability of directly observed therapy with peginterferon alfa-2a and once-daily ribavirin (RBV) for chronic hepatitis C in 49 opioid-addicted injection drug users. Sustained virological response was achieved by 98% of patients. Treatment was well tolerated, and no unexpected side effects of peginterferon treatment were seen. The safety profile of once-daily RBV was not different from twice-daily dosing.
Paper Details　
Original Abstract of the Article :
This retrospective study evaluated the efficacy and tolerability of directly observed therapy with peginterferon alfa-2a and once-daily ribavirin (RBV) for chronic hepatitis C in 49 opioid-addicted injection drug users (IDUs) participating in a drug treatment program at a specialized outpatient cent...See full text at original site
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引用元：
https://doi.org/10.1016/j.jsat.2010.02.002

データ提供：米国国立医学図書館（NLM）

Directly Observed Therapy for Hepatitis C in Injection Drug Users

Hepatitis C, a serious liver infection, is often associated with injection drug use. This study explores the effectiveness of directly observed therapy (DOT) for hepatitis C in a group of injection drug users. The study involved providing patients with peginterferon alfa-2a and ribavirin, along with regular monitoring and support. The results were quite positive, with 98% of patients achieving sustained virological response, meaning the virus was no longer detectable. The study also found that DOT was well-tolerated, with no unexpected side effects. This research suggests that DOT can be a safe and effective treatment option for hepatitis C in this population.

Hope for Hepatitis C Patients

These encouraging results provide hope for individuals struggling with hepatitis C. The high rate of sustained virological response demonstrates the potential of DOT to significantly improve the lives of these patients. It emphasizes the importance of providing comprehensive care, including medication, counseling, and support, to address the complex needs of individuals with hepatitis C.

Health Implications and Lifestyle Applications

This study highlights the importance of individualized treatment plans for those with hepatitis C. Directly observed therapy offers a structured approach that can be beneficial for individuals who may struggle with adherence to treatment. It also emphasizes the crucial role of social support and community resources in managing complex health conditions like hepatitis C.

Dr.Camel's Conclusion

The success of this study is like a cool oasis in the scorching desert of hepatitis C. It demonstrates the power of combined treatment approaches and highlights the importance of providing compassionate care to those in need. Just as a camel relies on a steady supply of water in the harsh desert, patients with hepatitis C require consistent support and treatment to achieve optimal outcomes.

Date :
  1. Date Completed 2010-07-23
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20362408

DOI: Digital Object Identifier

10.1016/j.jsat.2010.02.002

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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