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Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study.

Author: AnneseVito, BrandimarteGiovanni, D'AmicoTeresa, DaneseSilvio, Di GiulioEmilio, Di RosaSalvatore, EliseiWalter, FortiGiacomo, GasbarriniAntonio, GiglioAndrea, GiorgettiGian Marco, HassanCesare, ImeneoMaria, LarussaTiziana, LuzzaFrancesco, ModeoMaria Ester, MoriniSergio, PapaAlfredo, PistoiaMaria Antonietta, Rodino'Stefano, Sacca'Natale, SebkovaLadislava, TursiAntonio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the effects of VSL#3, a high-potency probiotic mixture, in patients with relapsing ulcerative colitis (UC) who are already under treatment with 5-aminosalicylic acid (ASA) and/or immunosuppressants. The study aimed to determine if VSL#3 supplementation could provide additional benefit in these patients.
Paper Details　
Original Abstract of the Article :
VSL#3 is a high-potency probiotic mixture that has been used successfully in the treatment of pouchitis. The primary end point of the study was to assess the effects of supplementation with VSL#3 in patients affected by relapsing ulcerative colitis (UC) who are already under treatment with 5-aminosa...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3180711/

データ提供：米国国立医学図書館（NLM）

Probiotics: A Potential Ally in Ulcerative Colitis Treatment

Ulcerative colitis, a chronic inflammatory bowel disease, can significantly impact an individual's quality of life. This study investigates the potential benefits of VSL#3, a high-potency probiotic mixture, as an adjunctive therapy for relapsing ulcerative colitis. The researchers conducted a double-blind, randomized, placebo-controlled trial, evaluating the effects of VSL#3 supplementation in patients already under treatment with standard medications. Their findings suggest that VSL#3 supplementation may improve clinical outcomes in patients with relapsing ulcerative colitis, indicating its potential as a supportive therapy for managing this debilitating condition.

Probiotics: A Promising Path to Improved Outcomes

This research highlights the potential of probiotics like VSL#3 as a supportive therapy for ulcerative colitis. The study's findings suggest that probiotics may enhance the effectiveness of standard treatments, leading to improved clinical outcomes and a better quality of life for patients. This research underscores the growing importance of the gut microbiome in health and disease, opening new avenues for therapeutic interventions.

The Importance of Gut Health

The gut microbiome plays a crucial role in maintaining overall health. This study underscores the potential benefits of modulating the gut microbiota through probiotic supplementation in managing inflammatory bowel diseases like ulcerative colitis. It emphasizes the need for further research to explore the mechanisms of action and optimize the use of probiotics for improving clinical outcomes.

Dr.Camel's Conclusion

This study is like a camel caravan discovering a lush oasis in the desert of inflammatory bowel disease research, highlighting the potential of probiotics in supporting the healing process. This research underscores the importance of nurturing a healthy gut microbiome for overall well-being, offering a new perspective on managing chronic inflammatory conditions.

Date :
  1. Date Completed 2010-10-25
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

20517305

DOI: Digital Object Identifier

PMC3180711

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