Side Effects of mesalamine rectal: A Synthesis of Findings from 29 Studies

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Original Abstract of the Article

Major findings of the study

Mesalamine is a drug that has been used for many years to treat ulcerative colitis. It is the active ingredient in sulfasalazine and is known to have fewer side effects than sulfasalazine. 13 Mesalamine has been shown to improve symptoms of ulcerative colitis and maintain remission. 8 Mesalamine is available in various formulations, such as oral and rectal. 8

Reasons for side effects

Side effects of mesalamine may occur when mesalamine is metabolized in the intestinal tract. 24 Mesalamine can bind to iron to generate reactive oxygen species, which can damage cells. 24 Also, mesalamine can be broken down by intestinal bacteria, which can produce toxic metabolites. 13 These metabolites may be the cause of side effects.

Common side effects

Gastrointestinal

Gastrointestinal side effects can occur when using mesalamine. 12 The most common side effects are diarrhea, abdominal pain, nausea, and vomiting. 12 Maldigestion, anorexia, and abdominal distention can also occur. 12 When using mesalamine rectal, local side effects such as anal irritation or pain may occur. 10 Mesalamine can bind to iron to generate reactive oxygen species, which can damage cells. 24 Mesalamine can be broken down by intestinal bacteria, which can produce toxic metabolites. 13 These metabolites may be the cause of gastrointestinal side effects.

Liver

Mesalamine may affect the liver. 24 Mesalamine can bind to iron to generate reactive oxygen species, which can damage liver cells. 24 Mesalamine can also be metabolized in the liver, leading to liver dysfunction. 24

Kidney

Mesalamine may affect the kidney. 24 Mesalamine can bind to iron to generate reactive oxygen species, which can damage kidney cells. 24 Mesalamine can also be metabolized in the kidney, leading to kidney dysfunction. 24

Others

Side effects such as headache, dizziness, rash, and itching can occur when using mesalamine. 13 Mesalamine may also cause allergic reactions. 13

Countermeasures for side effects

Gastrointestinal

Gastrointestinal side effects can occur when using mesalamine. If you are concerned about side effects, consult your doctor. Side effects may be reduced by dietary changes or medication. Mesalamine is more likely to cause gastrointestinal side effects when taken on an empty stomach. It should be taken after meals or between meals. Also, drinking plenty of water can reduce side effects. Drink water or tea frequently.

Liver

Mesalamine may affect the liver. If you are concerned about side effects, consult your doctor. Have your liver health checked regularly.

Kidney

Mesalamine may affect the kidney. If you are concerned about side effects, consult your doctor. Have your kidney health checked regularly.

Others

Side effects such as headache, dizziness, rash, and itching can occur when using mesalamine. If you are concerned about side effects, consult your doctor. Mesalamine may also cause allergic reactions. If you experience an allergic reaction, consult your doctor immediately.

Comparison between studies

Commonalities

Many studies have shown that mesalamine is effective in treating ulcerative colitis. 19 Mesalamine has been shown to improve symptoms of ulcerative colitis and maintain remission. 8 Mesalamine is known to have fewer side effects than sulfasalazine. 13

Differences

The efficacy and side effects of mesalamine may vary depending on the type and method of administration. 8 Various formulations of mesalamine have been developed, and the efficacy and side effects differ depending on the formulation. 6

Precautions for applying to real life

Mesalamine is used by many patients as a treatment for ulcerative colitis. 13 Mesalamine is generally a safe drug, but there is a possibility of side effects. 13 It is important to follow your doctor's instructions and be aware of side effects when using mesalamine. Various formulations of mesalamine have been developed. 6 The efficacy and side effects differ depending on the formulation, so consult your doctor and choose the formulation that is right for you.

Limitations of current research

Research on the side effects of mesalamine is still insufficient. Various formulations of mesalamine have been developed, and the efficacy and side effects differ depending on the formulation. 6 Further research is needed on the long-term safety and efficacy of mesalamine.

Future research directions

Further research is needed to better understand the side effects of mesalamine. The development of new treatments and formulations to reduce the side effects of mesalamine is also needed.

Conclusion

Mesalamine is used by many patients as a treatment for ulcerative colitis. Mesalamine is generally a safe drug, but there is a possibility of side effects. It is important to follow your doctor's instructions and be aware of side effects when using mesalamine. Various formulations of mesalamine have been developed. Consult your doctor and choose the formulation that is right for you.

Keywords
Benefit Keywords
Improved UC symptoms
Reduced colon inflammation
1
Few side effects
Treats left-sided colitis
2
Proctitis treatment
3
Proctitis treatment
4
Effective for ulcerative colitis
Fewer side effects
5
May prevent colorectal cancer
May treat diverticular disease
May treat irritable bowel syndrome
Prevents postsurgical relapse
Treats Crohn's disease
Treats IBD
Treats UC
6
Treatment of ulcerative colitis
7
Chemoprevention
Topical 5-ASA efficacy
UC remission
8
Improved telangiectasia
Reduced bleeding
9
High local concentration
Minimized systemic side effects
Ulcerative colitis treatment
10
Pouchitis treatment
UC treatment
11
UC treatment
12
Induces remission
Treats IBD
13
Ulcerative colitis treatment
14
Improved tolerance
Proctitis treatment
15
IBD management
Maintain remission
16
IBD remission
17
Few side effects
Ulcerative colitis relief
18
Induces remission
19
Ulcerative colitis treatment
20
Acceptable for long-term use
Maintain remission
21
Treats pouchitis
Treats ulcerative colitis
22
Reduced inflammatory bowel disease symptoms
23
Proctitis remission
Proctosigmoiditis remission
25
Improved IBD
Reduced corticosteroid need
26
Ulcerative colitis remission
27
Reduces side effects
Treats ulcerative colitis
28
Reduced side effects
29
Risk Keywords
Underused
5
Mild side effects
6
MMX formulation limitations
Sulfasalazine side effects
8
Difficulty retaining enema
Limited efficacy
10
Dose-related intolerance
Secretory diarrhea
12
Side effects
Unknown mechanism
13
Mild side effects
15
Steroid toxicity
16
Side effects of corticosteroids
17
Further research needed
Side effects
18
Minor side effects
19
None mentioned
21
Side effects
23
Adverse side effects
24
Mild side effects
25
None reported
28
Literature analysis of 29 papers
Positive Content
28
Neutral Content
0
Negative Content
1
Article Type
7
2
0
11
29
2.

Comparison of the efficiency of different enemas on patients with distal ulcerative colitis.

Author: ZhangYujie, ChenDi, WangFang, LiXiaowei, XueXianmin, JiangMingzuo, XuBing, ChuYi, WangWeijie, WuKaichun, MaoRen, ShenJun, YangShaoqi, LiangJie

Few side effects
Treats left-sided colitis

This abstract discusses the efficacy of rectal steroid and 5-aminosalicylic acid (5-ASA) enemas in treating distal ulcerative colitis (UC). Previous studies have shown that the combination is superior to using a single agent, but more research is needed to confirm this.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

4.

Budesonide Suppositories Are Effective and Safe for Treating Acute Ulcerative Proctitis.

Author: KruisWolfgang, NeshtaViacheslav, PesegovaMarina, AlekseevaOlga, AndreevPavel, DatsenkoOleksii, LevchenkoOlena, AbdulkhakovSayar, LozynskyyYuriy, MostovoyYuriy, SolovievKonstantin, DorofeyevAndrey E, ViethMichael, StiessMichael, GreinwaldRoland, MohrbacherRalf, SiegmundBritta

Proctitis treatment

This study compared the efficacy and safety of budesonide and mesalamine suppositories for treating proctitis.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Topical therapy is underused in patients with ulcerative colitis.

Author: SeiboldF, FournierN, BeglingerC, MottetC, PittetV, RoglerG,

Effective for ulcerative colitis
Fewer side effects
Underused

This study analyzed data from the Swiss IBD cohort study to investigate the use of topical therapy in patients with ulcerative colitis. The results showed that topical treatment was underused in patients with proctitis, suggesting that its potential benefits may not be fully realized.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

7.

[Topical therapy of ulcerative colitis].

Author: RoglerG, BeglingerC, MottetC, SeiboldF, GrossV

Treatment of ulcerative colitis

New topical medications for ulcerative colitis affecting the left side of the colon offer a better treatment option for many patients. Applying steroids and 5-aminosalicylic acid (5-ASA) rectally is associated with fewer side effects and is more effective than oral medications for mild to moderate left-sided colitis. While some believe that patients don't follow rectal treatments well, proper education about the benefits can improve compliance. Rectal medications are also effective for maintaining remission in distal colitis. New treatment guidelines now recommend topical therapies more often, and these papers specifically address the benefits of topical treatment for distal colitis, highlighting its advantages in everyday practice.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

8.

Is 5-ASA still the treatment of choice for ulcerative colitis?

Author: CottoneMario, RennaSara, ModestoIrene, OrlandoAmbrogio

Chemoprevention
Topical 5-ASA efficacy
UC remission
MMX formulation limitations
Sulfasalazine side effects

5-Amino-salacylic acid (5-ASA) is the treatment of choice for ulcerative colitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

Foam preparations for the treatment of ulcerative colitis.

Author: LoewBurr J, SiegelCorey A

High local concentration
Minimized systemic side effects
Ulcerative colitis treatment
Difficulty retaining enema
Limited efficacy

Topical rectal therapies, including foams, are recommended as first-line agents for ulcerative colitis limited to the left colon or rectal inflammation. Rectal foams offer advantages over suppositories and liquid enemas, including increased viscosity, lower volumes, finer dispersion on the colonic mucosa, and better patient tolerance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

11.

Treatment of relapsing mild-to-moderate ulcerative colitis with the probiotic VSL#3 as adjunctive to a standard pharmaceutical treatment: a double-blind, randomized, placebo-controlled study.

Author: TursiAntonio, BrandimarteGiovanni, PapaAlfredo, GiglioAndrea, EliseiWalter, GiorgettiGian Marco, FortiGiacomo, MoriniSergio, HassanCesare, PistoiaMaria Antonietta, ModeoMaria Ester, Rodino'Stefano, D'AmicoTeresa, SebkovaLadislava, Sacca'Natale, Di GiulioEmilio, LuzzaFrancesco, ImeneoMaria, LarussaTiziana, Di RosaSalvatore, AnneseVito, DaneseSilvio, GasbarriniAntonio

Pouchitis treatment
UC treatment

This study assessed the effects of VSL#3, a high-potency probiotic mixture, in patients with relapsing ulcerative colitis (UC) who are already under treatment with 5-aminosalicylic acid (ASA) and/or immunosuppressants. The study aimed to determine if VSL#3 supplementation could provide additional benefit in these patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

The metabolism of mesalamine and its possible use in colonic diverticulitis as an anti-inflammatory agent.

Author: CohenHillel D, DasKiron M

Induces remission
Treats IBD
Side effects
Unknown mechanism

This study discusses the development, metabolism, side effects, indications, and mechanisms of action of 5-aminosalicylic acid (5-ASA) releasing drugs. It also reviews the rationale for the clinical use of mesalamine in colonic diverticulitis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

14.

Comparative absorption of 5-aminosalicylic acid (5-ASA) after administration of a 5-ASA enema and salazosulfapyridine (SASP) after an SASP suppository in Japanese volunteers.

Author: TokuiKenji, AsaiYoshitaka, ArakawaToshiharu, MatsumotoTakatoshi, NabeshimaToshitaka

Ulcerative colitis treatment

This study compared the absorption and metabolism of salazosulfapyridine (SASP) and 5-aminosalicylic acid (5-ASA) after rectal administration. The study found that SASP is almost completely hydrolyzed in the colon, and 5-ASA is partially absorbed from the small intestine. The study concluded that rectal administration of 5-ASA is a promising approach for treating ulcerative colitis.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Comparative, open, randomized trial of the efficacy and tolerance of slow-release 5-ASA suppositories once daily versus conventional 5-ASA suppositories twice daily in the treatment of active cryptogenic proctitis: French Pentasa Study Group.

Author: MarteauP, FlorentC

Improved tolerance
Proctitis treatment
Mild side effects

Slow-release 5-ASA suppositories were as effective as conventional 5-ASA suppositories, but with greater patient tolerance and less frequent early expulsion.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Medical therapy of inflammatory bowel disease for the 21st century.

Author: RobinsonM

IBD management
Maintain remission
Steroid toxicity

New corticosteroids, particularly budesonide, may be less toxic than older agents. Topical and oral aminosalicylates are effective in treating mild to moderate UC and CD. Immunosuppressive drugs such as azathioprine and 6-mercaptopurine are effective for treating both CD and UC.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

18.

Nicotine enemas for active ulcerative colitis--a pilot study.

Author: GreenJ T, ThomasG A, RhodesJ, WilliamsG T, EvansB K, RussellM A, FeyerabendC, RhodesP, SandbornW J

Few side effects
Ulcerative colitis relief
Further research needed
Side effects

Topical nicotine therapy with enemas showed promise in treating active ulcerative colitis, improving symptoms and endoscopy scores in most patients, but further controlled studies are needed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

19.

Rectal corticosteroids versus alternative treatments in ulcerative colitis: a meta-analysis.

Author: MarshallJ K, IrvineE J

Induces remission
Minor side effects

Rectal 5-aminosalicylic acid (5-ASA) is more effective than rectal corticosteroids in treating distal ulcerative colitis, with a 2.42 odds ratio for symptom remission, 1.89 for endoscopy, and 2.03 for histology. 5-ASA is also less expensive than corticosteroids.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

20.

Low Pentasa dosage versus hydrocortisone in the topical treatment of active ulcerative colitis: a randomized, double-blind study.

Author: Bianchi PorroG, ArdizzoneS, PetrilloM, FasoliA, MolteniP, ImbesiV

Ulcerative colitis treatment

Short term topical treatment with a low dosage 5-aminosalicylic acid is at least as effective as 100-mg hydrocortisone enemas in treating mild to moderate distal ulcerative colitis and is generally well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

5-ASA enema versus oral sulphasalazine in maintaining remission in ulcerative colitis.

Author: AndreoliA, SpinellaS, LevensteinS, PranteraC

Acceptable for long-term use
Maintain remission
None mentioned

This study compared the efficacy of biweekly high-dose 5-aminosalicylic acid (5-ASA) enemas with oral sulphasalazine in maintaining remission in patients with left-sided ulcerative colitis. Both treatments were effective in maintaining remission, with no significant differences between the two, suggesting that biweekly 5-ASA enemas may be a viable alternative to oral sulphasalazine.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

22.

Cyclosporin A retention enemas in refractory distal ulcerative colitis and 'pouchitis'.

Author: WinterT A, DaltonH R, MerrettM N, CampbellA, JewellD P

Treats pouchitis
Treats ulcerative colitis

Cyclosporin enemas were safe and effective in treating severe refractory distal ulcerative colitis in 7 out of 12 patients. There was a strong correlation between clinical and histologic improvement. One patient with pouchitis also showed improvement.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

23.

[Local or systemic treatment of inflammatory bowel diseases?].

Author: SchmassmannA, HalterF

Reduced inflammatory bowel disease symptoms
Side effects

This review discusses the standard therapy of inflammatory bowel disease. The treatment options include corticosteroids, sulfasalazine, and 5-aminosalicylic acid. Topical therapy is preferred for ulcerative proctitis and left-sided colitis.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : German

24.

Prooxidant properties of 5-aminosalicylic acid. Possible mechanism for its adverse side effects.

Author: GrishamM B, WareK, MarshallS, YamadaT, SandhuI S

Adverse side effects

5-ASA can interact with iron to generate free radicals, which can damage biological compounds. This may explain some of the adverse side effects associated with 5-ASA preparations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

25.

[5-aminosalicylic acid enema (Pentasa) versus hydrocortisone acetate foam (Proctocort) for the treatment of outbreaks of proctitis and cryptogenetic proctosigmoiditis. A comparative randomized multicenter trial].

Author: NgôY, RambaudJ C

Proctitis remission
Proctosigmoiditis remission
Mild side effects

5-Aminosalicylic acid enema was more effective than hydrocortisone acetate foam in treating idiopathic proctitis or proctosigmoiditis. After 2 weeks, 67% of patients on 5-aminosalicylic acid achieved endoscopic remission compared to 50% on hydrocortisone.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : French

26.

[Chronic inflammatory bowel disease].

Author: MadsenJ R, LaursenL S, LauritsenK

Improved IBD
Reduced corticosteroid need

This article reviews the current understanding of chronic inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD). The article discusses the pathogenesis, diagnosis, and treatment of IBD. While corticosteroids and sulphasalazine are still the cornerstones of treatment, newer therapies including immunosuppressants and anti-leukotriene drugs are also discussed.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : Danish

27.

5-Aminosalicylic acid suppositories in the maintenance of remission in idiopathic proctitis or proctosigmoiditis: a double-blind placebo-controlled clinical trial.

Author: D'ArienzoA, PanareseA, D'ArmientoF P, LanciaC, QuattroneP, GiannattasioF, BoscainoA, MazzaccaG

Ulcerative colitis remission

5-aminosalicylic acid (5-ASA) suppositories were found to be effective in maintaining remission of distal ulcerative colitis. The cumulative remission rate at the 12th month was 92% in the 5-ASA group and 21% in the placebo group. No side effects were observed.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

28.

Rowasa suspension enema (mesalamine, USP).

Author: CiarleglioC A

Reduces side effects
Treats ulcerative colitis
None reported

Rowasa (mesalamine) rectal suspension enema is a new treatment for distal ulcerative colitis. It offers an alternative to oral medications and may reduce side effects.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

29.

[New treatments of hemorrhagic rectocolitis].

Author: RambaudJ C

Reduced side effects

New formulations of 5-aminosalicylic acid (5-ASA) have improved the treatment of ulcerative colitis by allowing for targeted delivery to the colon with fewer side effects.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

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