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Single administration of alpha-glucosidase inhibitors on endothelial function and incretin secretion in diabetic patients with coronary artery disease - Juntendo University trial: effects of miglitol on endothelial vascular reactivity in type 2 diabetic patients with coronary heart disease (J-MACH) -.

Author: DaidaHiroyuki, FukaoKosuke, FukushimaYoshifumi, HikiMakoto, HiroseKuniaki, KiyanagiTakashi, KumeAtsumi, KurataTakeshi, MatsumoriRie, MiidaTakashi, MiyazakiTetsuro, OhmuraHirotoshi, OhsakaHiromichi, ShimadaKazunori, SumiyoshiKatsuhiko

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.

Overview

This study aims to investigate the post-prandial effects of alpha-glucosidase inhibitors (alpha-GIs) on endothelial function and incretin secretion in type 2 diabetic patients with coronary artery disease (CAD). The study explores the potential for alpha-GIs to improve post-prandial hyperglycemia, hyperlipidemia, and endothelial dysfunction, all factors contributing to the development of atherosclerosis.
Paper Details　
Original Abstract of the Article :
Post-prandial hyperglycemia, hyperlipidemia, and endothelial dysfunction play an important role in the pathogenesis of atherosclerosis. Improvement in post-prandial hyperglycemia on alpha-glucosidase inhibitors (alpha-GIs) is associated with a risk reduction of cardiovascular diseases, but the post-...See full text at original site
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引用元：
https://doi.org/10.1253/circj.cj-10-0013

データ提供：米国国立医学図書館（NLM）

Alpha-Glucosidase Inhibitors: A Promising Approach to Post-Prandial Hyperglycemia in Diabetic Patients

[Diabetes] is a complex metabolic disorder that requires a multifaceted approach to management. This study investigates the effects of [alpha-glucosidase inhibitors (alpha-GIs)], a class of drugs, on [endothelial function] and [incretin secretion] in [diabetic patients with coronary artery disease (CAD)]. This is like searching for a sustainable oasis in the desert of [diabetes] research, exploring different strategies to improve the lives of patients living with this condition.

Miglitol: Improving Endothelial Function in Diabetic Patients with CAD

The study focused on the effects of [miglitol], a specific [alpha-GI], on [endothelial vascular reactivity] in [type 2 diabetic patients with CAD]. The results suggest that [miglitol] might have a positive impact on [endothelial function] in this patient population. This is like finding a new irrigation system that revitalizes the desert landscape, improving the overall health of the ecosystem.

Alpha-Glucosidase Inhibitors: A New Avenue in Diabetes Management

This study provides valuable insights into the potential benefits of [alpha-GIs] in managing [post-prandial hyperglycemia] in [diabetic patients with CAD]. This research is like discovering a new well in the desert, offering a source of relief and support for patients facing the challenges of [diabetes] and [heart disease]. Further research is needed to fully understand the long-term effects of [alpha-GIs] on [endothelial function] and [incretin secretion] in [diabetic patients with CAD].

Dr. Camel's Conclusion

This study adds to the growing body of evidence supporting the use of [alpha-GIs] in managing [diabetes]. The potential benefits of these medications extend beyond simply controlling [blood sugar] levels, suggesting a wider role in improving overall cardiovascular health. As researchers continue to explore the complexities of [diabetes] and [heart disease], we may uncover even more effective and personalized treatment options that improve the lives of patients living with these conditions.
Date :
  1. Date Completed 2010-10-19
  2. Date Revised 2019-08-19
Further Info :

Pubmed ID

20519875

DOI: Digital Object Identifier

10.1253/circj.cj-10-0013

Related Literature

Article Analysis
・Effects of miglitol
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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