Paper Details

  1. Home
  2. Paper Details

Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.

Author: HuYongjun, JiangHuidi, KeepRichard F, SmithDavid E, XiangJianming

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated how the body breaks down neuropeptides, which are small signaling molecules that play an important role in the nervous system. The study found that a specific transporter protein is involved in the removal of neuropeptides from the body.
Paper Details　
Original Abstract of the Article :
Neuropeptide inactivation is generally thought to occur via peptidase-mediated degradation. However, a recent study found increased analgesia after L-kyotorphin (L-Tyr-L-Arg; L-KTP) administration in mice lacking an oligopeptide transporter, PEPT2. The current study examines the role of PEPT2 in L-K...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://pubmed.ncbi.nlm.nih.gov/20537989

データ提供：米国国立医学図書館（NLM）

Kyotorphin: A Journey Through the Desert of the Brain

Greetings, fellow explorers! Dr. Camel here, and I'm always fascinated by the complexities of the brain, a true desert of knowledge. This study investigates kyotorphin, a neuropeptide that plays a role in pain signaling. Imagine a desert caravan, traveling across a vast and unforgiving landscape. Kyotorphin is like a message sent from one oasis to another, carrying information about the journey's challenges.

The researchers explored the transport and metabolism of kyotorphin in astrocytes, star-shaped cells that support neurons in the brain. They found that astrocytes both transport and degrade kyotorphin, like a desert oasis that both attracts and eventually consumes water.

The Desert's Hidden Oasis

The researchers discovered that kyotorphin is transported by a specific transporter protein called PEPT2. It's like a special camel that carries the message from one oasis to another, ensuring it reaches its destination.

Navigating the Desert of Pain

This research sheds light on the complex mechanisms of pain signaling in the brain. It's like unraveling the hidden secrets of the desert, understanding the intricate network of pathways that connect its diverse landscapes.

Dr.Camel's Conclusion

This research provides valuable insights into the transport and metabolism of kyotorphin in astrocytes. It's a reminder that even within the seemingly simple desert, complex processes are constantly at work.

Date :
  1. Date Completed 2010-11-02
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20537989

DOI: Digital Object Identifier

NIHMS218129

Related Literature

Article Analysis
・Effects of cefadroxil
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.