Effects of cefadroxil: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Main Research Findings

Cefadroxil has been shown to have antinociceptive effects in experimental animal models of pain. 10 . Cephalosporins, such as cefadroxil, can enhance glutamate transporter-1 expression in astrocytes, which helps recycle glutamate from the synaptic cleft, and has analgesic properties in animals and humans with chronic pain. 10 . Cefadroxil has also been studied in combination with amikacin in a rabbit model of colonic anastomosis to observe the effects on the anastomosis site. . In neonatal rat and mouse astrocytes, cefadroxil affects the uptake and metabolism of L-kyotorphin. 2 . Cefadroxil is part of a novel cephalosporin synthesized through amination of 2,5-dihydroxybenzoic acid derivatives using fungal laccases. 16 . Cefadroxil has been shown to inhibit the growth of several Gram-positive bacteria. 16 . Cefadroxil has been used in the development of a broad-spectrum competitive ELISA kit for the detection of first-generation cephalosporin antibiotics in animal-derived foods. 9 . Cefadroxil is a substrate of PEPT2, and its pharmacokinetics, dynamics, and toxicity are influenced by this transporter. 15 . Cefadroxil was one of 10 cephalosporin antibiotics tested against Staphylococcus pseudintermedius in dogs. 19 . Cefadroxil has been associated with a high prevalence of multi-drug resistance in Enterococcus faecalis in Egyptian patients with urinary tract infections, which poses a significant challenge for treating infections caused by this organism in Egypt. 20 . Cefadroxil, along with cefixime and ceftriaxone, have been reported as GSK3β covalent inhibitors, suggesting their potential for treating cancer and Alzheimer's disease. . Cefadroxil's pharmacokinetics in mice were influenced by lipopolysaccharide-induced inflammation. 17 . Similar to sartans, cefadroxil interacts with H+/peptide transporters but is not itself transported. 8 . Cefadroxil affects the pharmacokinetics of cefdinir in rats. 18 . Cefadroxil was used to investigate the relationship between the occurrence of plasmids and antibiotic resistance in Myroides odoratimimus. 21 . Cefadroxil is a substrate for MacQ, a novel quorum-quenching N-acylhomoserine lactone acylase produced by Acidovorax sp. strain MR-S7. 5 . Cefadroxil was part of a study to optimize the penicillin V industrial bioreactor train. 6 . Cefadroxil was one of the beta-lactam antibiotics used to study the effects of ethanol on intestinal absorption and excretion in rats. 4 . Cefadroxil has been linked to transient Fanconi syndrome when administered with firocoxib, tramadol, and famotidine in Maltese dogs. 14 . Cefadroxil was used in a study assessing the cost-effectiveness of extended oral antibiotic prophylaxis for preventing infection after total joint arthroplasty in high-risk patients. 13 . Cefadroxil has been associated with DRESS syndrome, a drug reaction, which can be confirmed through a positive patch test. . Cefadroxil was utilized in an in vitro model to evaluate the urinary bactericidal activity against common urinary tract pathogens. 11 . Cefadroxil is recommended as an alternative treatment for β-hemolytic streptococci in clinical practice guidelines for the diagnosis and nonsurgical management of tonsillitis. 12 . Cefadroxil was used in a case report describing a hybrid approach involving the drainage of a periaortic graft abscess and transcatheter aortic valve replacement in the same setting. 22 . Cefadroxil was used as a comparison point in the revision of Clinical and Laboratory Standards Institute breakpoints for cefazolin against Enterobacteriaceae. 7 .

Benefits and Risks

Benefit Summary

Cefadroxil is an effective antibiotic for treating bacterial infections. 16 . It has been shown to have antinociceptive effects in animal models. 10 . Cefadroxil's ability to enhance glutamate transporter-1 expression in astrocytes suggests potential for treating chronic pain in humans. 10 .

Risk Summary

Cefadroxil can cause side effects, such as DRESS syndrome, a serious drug reaction. . Cefadroxil can interact with other medications, potentially reducing its effectiveness or increasing side effects. 8 . Cefadroxil is metabolized by the kidneys, so caution should be exercised in patients with reduced kidney function. 18 .

Research Comparisons

Research Similarities

Many studies indicate that cefadroxil is an effective antibiotic for treating bacterial infections. 16 , 19 , 20 . Additionally, studies have shown that cefadroxil can interact with other medications. 8 , 18 .

Research Differences

Cefadroxil has been demonstrated to have antinociceptive effects in animal models. 10 . Cefadroxil, along with cefixime and ceftriaxone, has been identified as a GSK3β covalent inhibitor, suggesting its potential for treating cancer and Alzheimer's disease. . These effects have not been reported in other studies.

Consistency and Contradictions in Results

Cefadroxil is generally considered a safe antibiotic. 16 , 19 , 20 . However, it has the potential to cause side effects, such as DRESS syndrome. . It can also interact with other medications. 8 , 18 . Further research is needed to explain these contradictory results.

Real-World Applications and Considerations

Cefadroxil is an effective antibiotic for treating bacterial infections. 16 , 19 , 20 . However, it has the potential to cause side effects, such as DRESS syndrome. . It can also interact with other medications. 8 , 18 . It is important to follow your doctor's instructions when taking cefadroxil.

Limitations of Current Research

Many studies involving cefadroxil are conducted using animal models. 10 , , 2 . Therefore, it is not possible to directly apply these findings to humans. Further research is needed to thoroughly investigate cefadroxil's effects in humans.

Future Research Directions

Further research on cefadroxil should focus on its effects in humans, particularly in relation to chronic pain. 10 . Investigating the interactions between cefadroxil and other medications is also crucial. 8 , 18 . Additionally, understanding how cefadroxil causes side effects like DRESS syndrome needs to be explored. .

Conclusion

Cefadroxil is an effective antibiotic for treating bacterial infections. 16 , 19 , 20 . However, it can cause side effects, such as DRESS syndrome. . It can also interact with other medications. 8 , 18 . It is essential to follow your doctor's instructions when taking cefadroxil.

Literature analysis of 22 papers
Positive Content
18
Neutral Content
1
Negative Content
3
Article Type
0
1
1
2
21
2.

Kyotorphin transport and metabolism in rat and mouse neonatal astrocytes.

Author: XiangJianming, JiangHuidi, HuYongjun, SmithDavid E, KeepRichard F

Analgesia

This study investigated how the body breaks down neuropeptides, which are small signaling molecules that play an important role in the nervous system. The study found that a specific transporter protein is involved in the removal of neuropeptides from the body.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Interventions for bacterial folliculitis and boils (furuncles and carbuncles).

Author: LinHuang-Shen, LinPei-Tzu, TsaiYu-Shiun, WangShu-Hui, ChiChing-Chi

Reduced boils
Reduced folliculitis

This systematic review examined the available treatments for bacterial folliculitis and boils.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

4.

Effects of ethanol on the pharmacokinetics of cephalexin and cefadroxil in the rat.

Author: Barrio LeraJ P, AlvarezA I, PrietoJ G

Decreases antibiotic absorption

Ethanol decreased intestinal absorption of cephalexin and cefadroxil in rats, with varying effects on their excretion.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Multi-objective optimization of an industrial penicillin V bioreactor train using non-dominated sorting genetic algorithm.

Author: LeeFook Choon, RangaiahGade Pandu, RayAjay Kumar

Penicillin production optimization

This paper presents an optimization study of an industrial penicillin V bioreactor train for multiple objectives simultaneously. Using NSGA-II, the study successfully obtained a range of optimal design and operating conditions for key performance indicators, showcasing trade-offs between different objectives.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Cefazolin and enterobacteriaceae: rationale for revised susceptibility testing breakpoints.

Author: TurnidgeJohn D,

Improved dosing
Revised breakpoints

Cefazolin is an antibiotic that is used to treat bacterial infections. New guidelines for the use of cefazolin against Enterobacteriaceae have been developed based on recent research. These guidelines recommend increasing the minimum inhibitory concentration for cefazolin. This change is linked to a recommended adult dosage of 2 g every 8 hours intravenously.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

High-affinity interaction of sartans with H+/peptide transporters.

Author: KnütterIlka, KottraGabor, FischerWiebke, DanielHannelore, BrandschMatthias

Heart failure treatment
Hypertension treatment

Sartans, a class of drugs used for hypertension and other cardiovascular disorders, were investigated for their interaction with peptide transporters. Losartan, irbesartan, valsartan, and eprosartan inhibited the uptake of dipeptides, suggesting they interact with peptide transporters but are not transported themselves.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

11.

Urinary bactericidal activity of oral antibiotics against common urinary tract pathogens in an ex vivo model.

Author: BedenicBranka, TopicMarijana, BudimirAna, BubonjaMarina

Urinary tract infection treatment
Low bactericidal activity

Fluoroquinolones displayed high and persisting levels of urinary bactericidal activity against all gram-negative bacteria and Staphylococcus saprophyticus.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

12.

Clinical practice guideline: tonsillitis I. Diagnostics and nonsurgical management.

Author: WindfuhrJochen P, ToepfnerNicole, SteffenGregor, WaldfahrerFrank, BernerReinhard

Tonsillitis treatment

This guideline provides a multi-disciplinary approach to managing acute tonsillitis, focusing on conservative treatment options. It recommends using a diagnostic scoring system to identify β-hemolytic streptococci and outlines appropriate antibiotic regimens. The guideline also emphasizes the importance of avoiding unnecessary blood tests and other investigations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.

Language : English

13.

The Cost-Effectiveness of Extended Oral Antibiotic Prophylaxis for Infection Prevention After Total Joint Arthroplasty in High-Risk Patients.

Author: LipsonSophie, PaganiNicholas R, MovermanMichael A, PuzzitielloRichard N, MenendezMariano E, SmithEric L

PJI prevention

This study used a break-even economic model to determine the cost-effectiveness of extended oral antibiotic prophylaxis for PJI prevention in high-risk TJA patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

14.

Transient Fanconi Syndrome After Treatment with Firocoxib, Cefadroxil, Tramadol, and Famotidine in a Maltese.

Author: AhnJin-Ok, KimSang-Min, SongWoo-Jin, RyuMin-Ok, LiQiang, ChungJin-Young, YounHwa-Young

Renal toxicity

This case report describes a dog with transient Fanconi syndrome after administration of firocoxib, cefadroxil, tramadol, and famotidine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

15.

Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity.

Author: KamalMohamed A, KeepRichard F, SmithDavid E

Drug disposition modulation

Pept2 knockout mice are an important tool to study the role of the proton-coupled oligopeptide transporter.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

16.

Novel cephalosporins synthesized by amination of 2,5-dihydroxybenzoic acid derivatives using fungal laccases II.

Author: MikolaschAnnett, NiedermeyerTimo Horst Johannes, LalkMichael, WittSabine, SeefeldtSimone, HammerElke, SchauerFrieder, Gesell SalazarManuela, HesselSusanne, JülichWolf-Dieter, LindequistUlrike

antibiotic development

Sixteen novel cephalosporins were synthesized using laccases from Trametes sp. or Myceliophthora thermophila. All products inhibited the growth of several Gram-positive bacterial strains, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant enterococci. The products also protected mice against a lethal infection with Staphylococcus aureus. The new compounds have negligible cytotoxicity and acute toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil.

Author: HuhYeamin, KeepRichard F, SmithDavid E

Cefadroxil disposition

Cefadroxil is an antibiotic that is primarily excreted by the kidneys. This study in mice found that lipopolysaccharide-induced inflammation significantly reduces renal clearance of cefadroxil, leading to increased plasma concentrations of the drug. These findings suggest that careful monitoring of cefadroxil levels is important in patients with acute inflammation.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

18.

Effects of 1α,25-dihydroxyvitamin D3 , the natural vitamin D receptor ligand, on the pharmacokinetics of cefdinir and cefadroxil, organic anion transporter substrates, in rat.

Author: KimYu Chul, KimIn-Bong, NohChi-Kyoung, QuachHolly P, YoonIn-Soo, ChowEdwin C Y, KimMyungsoo, JinHyo-Eon, ChoKwan Hyung, ChungSuk-Jae, PangK Sandy, MaengHan-Joo

This study investigates the impact of 1α,25-dihydroxyvitamin D3 [1,25(OH)2 D3] on the pharmacokinetics of cefdinir and cefadroxil, two cephalosporin antibiotics, in rats. The study finds that 1,25(OH)2 D3 treatment increases the levels of these drugs in the blood by decreasing their clearance, potentially due to downregulation of renal OAT transporters.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

In vitro comparison of Staphylococcus pseudintermedius susceptibility to common cephalosporins used in dogs.

Author: WestermeyerRebekah R, RoyAlma F, MitchellMaria S, MerchantSandra R

Staphylococcus pseudintermedius treatment

The study found that cephalothin, cefovecin, and cefazolin were the most active cephalosporin antimicrobial agents against methicillin-susceptible Staphylococcus pseudintermedius isolates from dogs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

21.

Relationship between plasmid occurrence and antibiotic resistance in Myroides odoratimimus SKS05-GRD isolated from raw chicken meat.

Author: SuganthiRamasamy, Shanmuga PriyaThangavel, SaranyaAsokan, KaleeswaranThangaraj

Antibiotic sensitivity
Antibiotic resistance

Myroides odoratimimus was found to be resistant to several antibiotics, with resistance to amikacin, gentamicin, and kanamycin confirmed to be plasmid-mediated.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

22.

Successful drainage of periaortic graft abscess and transcatheter aortic valve replacement in the same setting-A hybrid approach.

Author: NasserAhmed S, El KhateebOsama, StewartKeir, AliterHashem

Hybrid approach
High mortality risk

This case report describes a hybrid approach for managing a periaortic graft abscess and severe aortic stenosis in an 81-year-old man. The patient underwent abscess drainage and transcatheter aortic valve replacement, highlighting the benefits of a multidisciplinary approach for high-risk cardiovascular patients.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Language : English

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