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Nocebo effects in multiple sclerosis trials: a meta-analysis.

Author: MitsikostasD D, PapadopoulosD

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Nocebo responses are a significant issue in multiple sclerosis (MS) trials. The pooled incidence of nocebo responses was significantly higher in disease-modifying treatment (DMT) trials (74.4%) compared to symptomatic treatment (ST) trials (25.3%). The severity of nocebo responses, as measured by dropout due to adverse events, was similar between DMT and ST trials (2.1% vs. 2.34%). These findings highlight the importance of addressing nocebo effects in MS research and clinical practice.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: To estimate the incidence and severity of nocebo responses in trials of symptomatic treatments (STs) and disease-modifying treatments (DMTs) for multiple sclerosis (MS). METHODS: We conducted a systematic Medline search for all randomised, placebo-controlled MS trials published between 1...See full text at original site
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引用元：
https://doi.org/10.1177/1352458510370793

データ提供：米国国立医学図書館（NLM）

Nocebo Effects in Multiple Sclerosis: The Shadow in the Desert of Treatment

In the vast desert of multiple sclerosis (MS) research, finding effective treatments is a constant struggle. This meta-analysis explores the nocebo effect, a hidden shadow that can sabotage these efforts, casting doubt on the effectiveness of both symptomatic and disease-modifying treatments.

The Nocebo Effect: A Mirage in the Desert

The meta-analysis revealed a significant nocebo effect in MS trials, with a substantial proportion of placebo-treated patients experiencing adverse events. This is like a mirage in the desert, where a seemingly promising oasis turns out to be an illusion. The nocebo effect can make it difficult to determine the true efficacy of new treatments.

Navigating the Desert of MS Treatment

Understanding and minimizing the nocebo effect is crucial for the development and evaluation of MS treatments. This is like learning to differentiate mirages from real oases, navigating the desert of MS research with a keen eye for potential pitfalls.

Dr.Camel's Conclusion

The nocebo effect in MS trials presents a major challenge for researchers and clinicians. It's a reminder that even in the desert of medical research, the power of the mind can have a profound impact on the perceived effectiveness of treatments.

Date :
  1. Date Completed 2010-10-26
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

20538704

DOI: Digital Object Identifier

10.1177/1352458510370793

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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