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[Side effects of nifedipine in healthy probands within the scope of a discontinued bioavailability study].

Author: BandittP, MeyerF P, WaltherH

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Cardiovascular side effects associated with nifedipine retard dragees may occur at serum levels of 80 ng/ml or higher, as observed in a bioavailability study. A correlation between side effect severity and the area under the concentration vs. time curve (AUC) was suggested.
Paper Details　
Original Abstract of the Article :
In a prematurely discontinued bioavailability study of 40 mg nifidepine retard dragees, it was shown in four subjects that cardiovascular side effects may occur at nifedipine levels equal to or higher than some 80 ng/ml serum. These cases were suggestive of a relationship between the areas under the...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2058214

データ提供：米国国立医学図書館（NLM）

Side Effects of Nifedipine in Healthy Probands

This study investigates the potential side effects of nifedipine, a medication commonly used to treat high blood pressure and chest pain. The research involved a prematurely discontinued bioavailability study of nifedipine retard dragees. The study found that cardiovascular side effects could occur at nifedipine serum levels equal to or higher than 80 ng/ml. The researchers observed a correlation between the area under the concentration-time curve (AUC) and the severity of side effects.

Nifedipine: A Potential for Side Effects

The study highlights the importance of monitoring nifedipine levels to mitigate the risk of cardiovascular side effects. It provides valuable information for healthcare professionals prescribing nifedipine, emphasizing the need for careful dose adjustments and patient monitoring.

Understanding the Risks of Nifedipine

While nifedipine is an effective medication for treating certain conditions, it's important to be aware of its potential side effects. Patients taking nifedipine should discuss any concerns or side effects they experience with their healthcare providers.

Dr.Camel's Conclusion

Just like a camel can be affected by changes in the desert environment, even seemingly helpful medications like nifedipine can have unintended consequences. This research underscores the importance of understanding the potential side effects of any medication and working closely with healthcare providers to minimize risks and optimize outcomes.

Date :
  1. Date Completed 1991-07-31
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2058214

DOI: Digital Object Identifier

2058214

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・Side Effects of nifedipine
SNS
PICO Info
in preparation
Languages

German

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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