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Pharmacogenetic testing and therapeutic drug monitoring are complementary tools for optimal individualization of drug therapy.

Author: BenítezJulio, CarrilloJuan Antonio, GervasiniGuillermo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review discusses the challenges and limitations of translating pharmacogenetic findings into clinical practice. While pharmacogenetic research has made significant progress, its application remains limited due to complex factors such as multigenic drug responses, the interplay between genetics and environment, and various barriers to implementation. The authors highlight the potential role of therapeutic drug monitoring as an alternative or complementary approach to personalized drug therapy.
Paper Details　
Original Abstract of the Article :
Genetic factors contribute to the phenotype of drug response, but the translation of pharmacogenetic outcomes into drug discovery, drug development or clinical practice has proved to be surprisingly disappointing. Despite significant progress in pharmacogenetic research, only a few drugs, such as ce...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-010-0857-7

データ提供：米国国立医学図書館（NLM）

Pharmacogenetics and Therapeutic Drug Monitoring: A Two-Pronged Approach to Personalized Medicine

This research delves into the exciting world of personalized medicine, exploring the use of pharmacogenetics and therapeutic drug monitoring to optimize drug therapy. It's like having two powerful tools for navigating the vast desert of individual differences in drug response. The authors discuss the challenges and opportunities presented by pharmacogenetics, highlighting its potential to personalize treatment based on genetic variations. They also emphasize the complementary role of therapeutic drug monitoring, which involves measuring drug levels in the body to ensure optimal dosage and minimize side effects. This research is like a treasure hunt, seeking to unlock the secrets of personalized medicine and improve patient outcomes.

A Powerful Duo: Pharmacogenetics and Therapeutic Drug Monitoring

This research highlights the potential of combining pharmacogenetics and therapeutic drug monitoring to create a more personalized approach to drug therapy. This strategy could help optimize drug effectiveness, minimize side effects, and tailor treatment regimens based on individual genetic profiles and drug levels.

A Personalized Approach: Tailoring Treatment to Individual Needs

This research underscores the importance of embracing personalized medicine, recognizing that individuals respond to medications differently. By combining pharmacogenetics and therapeutic drug monitoring, we can move closer to a future where drug therapy is tailored to each patient's unique needs, leading to better outcomes and fewer side effects.

Dr. Camel's Conclusion

This research, like a compass and map combined, guides us toward a future of personalized medicine. It highlights the potential of pharmacogenetics and therapeutic drug monitoring to optimize drug therapy, ensuring a smoother and more effective journey for patients.

Date :
  1. Date Completed 2011-01-20
  2. Date Revised 2022-08-01
Further Info :

Pubmed ID

20582584

DOI: Digital Object Identifier

10.1007/s00228-010-0857-7

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English

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