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A randomised trial evaluating the safety and immunogenicity of the novel single oral dose typhoid vaccine M01ZH09 in healthy Vietnamese children.

Author: BudhramRonald, CampbellJames I, CaoThu Thuy, DolecekChristiane, DouganGordon, FarrarJeremy, GloverClare, LamWinnie, MarquesFilipe, MayJames P, NguyenThanh Truong, NguyenThi Cam Binh, NguyenThi Dung, NguyenVan Minh Hoang, NguyenVan Vinh Chau, NinhThi Thanh Van, PhamVan Minh, PhamVan Toi, SchultszConstance, SimmonsCameron P, StockwellElaine, ToSong Diep, TranNguyen Bich Chau, TranThi Diem Ha, TranThi Thu Nga, TranTinh Hien, UptonAnthony

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new single-dose oral typhoid vaccine, M01ZH09, containing Salmonella enterica serovar Typhi with two attenuating deletions, has shown immunogenicity and acceptable safety in healthy adults. This vaccine holds promise for addressing the growing issue of drug-resistant typhoid fever, particularly in Asia.
Paper Details　
Original Abstract of the Article :
The emergence of drug resistant typhoid fever is a major public health problem, especially in Asia. An oral single dose typhoid vaccine would have major advantages. M01ZH09 is a live oral single dose candidate typhoid vaccine containing Salmonella enterica serovar Typhi (Ty2 aroC(-)ssaV(-)) ZH9 with...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2909895/

データ提供：米国国立医学図書館（NLM）

A Single Dose Solution in the Desert of Typhoid Fever: M01ZH09 Vaccine

Typhoid fever, a serious bacterial infection, continues to pose a significant threat in many parts of the world. The emergence of drug-resistant strains has made treatment more challenging. This study investigated the safety and immunogenicity of a novel single oral dose typhoid vaccine, M01ZH09, in healthy Vietnamese children.

A New Oasis: M01ZH09 Vaccine for Typhoid Fever

The study found that M01ZH09 was well-tolerated and elicited an immune response in the children. This suggests that a single oral dose vaccine could be a valuable tool for preventing typhoid fever in children, offering a more convenient and potentially more effective approach to vaccination. It's like finding a compact and reliable source of protection in a desert of disease.

Combatting Typhoid Fever: A Single Dose Solution

The research offers hope for controlling typhoid fever, especially in regions where access to healthcare can be limited. A single oral dose vaccine could be a game changer in preventing the spread of this serious disease. It's like finding a portable oasis of protection, making it easier to reach and benefit those in need.

Dr.Camel's Conclusion

This research highlights the importance of developing innovative vaccine strategies to combat infectious diseases. A single oral dose vaccine, like discovering a wellspring of immunity in the desert, offers a simple and effective solution for preventing the spread of disease and protecting vulnerable populations.

Date :
  1. Date Completed 2010-10-28
  2. Date Revised 2022-12-07
Further Info :

Pubmed ID

20668668

DOI: Digital Object Identifier

PMC2909895

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PICO Info
in preparation
Languages

English

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