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Double-blind, placebo-controlled study of azelastine and fluticasone in a single nasal spray delivery device.

Author: AmarN J, DaftaryPramila, HampelFrank C, RatnerPaul H, SacksHarry, Van BavelJulius, WheelerWilliam

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A combination of azelastine and fluticasone nasal spray provided statistically significant improvement in nasal symptoms and greater benefit compared to either agent alone in patients with moderate-to-severe seasonal allergic rhinitis.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A proof-of-concept study suggested that combination therapy with commercial azelastine hydrochloride nasal spray and fluticasone propionate nasal spray significantly improved nasal symptoms of seasonal allergic rhinitis compared with either agent alone. OBJECTIVE: To compare an azelasti...See full text at original site
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引用元：
https://doi.org/10.1016/j.anai.2010.06.008

データ提供：米国国立医学図書館（NLM）

Azelastine and Fluticasone: A Powerful Alliance Against Seasonal Allergic Rhinitis

Seasonal allergic rhinitis, a common ailment that can make life miserable for those who suffer from it, often brings a relentless barrage of sneezing, runny nose, and itchy eyes. This research, like a camel seeking refuge from a sandstorm, explores the potential of combining two nasal sprays, azelastine and fluticasone, to provide relief from the symptoms of seasonal allergic rhinitis. The authors delve into the effectiveness and safety of this combination therapy, comparing it to individual treatments.

A Powerful Alliance: Azelastine and Fluticasone for Seasonal Allergic Rhinitis

The study revealed that the combination of azelastine and fluticasone, administered as a single nasal spray, provided significantly greater improvement in nasal symptoms compared to either agent alone. This research highlights the potential for synergistic effects when combining different therapeutic approaches, leading to enhanced patient outcomes.

Finding Relief from the Desert Storm of Allergies: A Combination Approach

This research offers a promising solution for patients suffering from seasonal allergic rhinitis. The combination of azelastine and fluticasone, administered as a single nasal spray, provides an effective and convenient option for alleviating symptoms and improving quality of life.

Dr.Camel's Conclusion

This research, like a refreshing oasis in the desert of allergy symptoms, offers a beacon of hope for individuals seeking relief. The combination of azelastine and fluticasone, administered as a single nasal spray, provides a powerful and effective option for managing seasonal allergic rhinitis. This research underscores the importance of exploring synergistic effects in combination therapies, leading to enhanced treatment outcomes and improved patient care.

Date :
  1. Date Completed 2010-11-03
  2. Date Revised 2022-03-30
Further Info :

Pubmed ID

20674829

DOI: Digital Object Identifier

10.1016/j.anai.2010.06.008

Related Literature

Article Analysis
・Effects of fluticasone nasal spray
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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