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Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures.

Author: ChonchaiyaWeerasak, EthellIryna M, FaradzSultana M H, HagermanRandi J, NguyenDanh V, RiveraSusan M, SchneiderAndrea, UtariAgustini

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This review summarizes the potential use of minocycline for treating fragile X syndrome, based on its ability to rescue dendritic spine and synaptic abnormalities in a mouse model. A preliminary survey of 50 patients with fragile X syndrome who received minocycline indicates gastrointestinal difficulties as the most common side effect and reported improvements in language and behavior. However, further research, including randomized clinical trials, is necessary to determine minocycline's efficacy in treating fragile X syndrome.
Paper Details　
Original Abstract of the Article :
Minocycline can rescue the dendritic spine and synaptic structural abnormalities in the fragile X knock-out mouse. This is a review and preliminary survey to document side effects and potential outcome measures for minocycline use in the treatment of individuals with fragile X syndrome. We surveyed ...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/20687826

データ提供：米国国立医学図書館（NLM）

Fragile X Syndrome: Exploring New Horizons in Treatment

Fragile X syndrome, a genetic disorder affecting cognitive development, is a challenging condition for both individuals and their families. This research explores the potential therapeutic benefits of minocycline, a drug known to rescue dendritic spine and synaptic structural abnormalities in Fragile X knockout mice. The authors provide a comprehensive overview of the current understanding of minocycline's potential, including its potential side effects and the importance of conducting randomized clinical trials to definitively evaluate its efficacy.

Minocycline: A Potential Oasis in the Treatment of Fragile X Syndrome

This research explores the potential therapeutic benefits of minocycline in the treatment of Fragile X syndrome, a genetic disorder affecting cognitive development. The authors highlight the drug's ability to rescue dendritic spine and synaptic structural abnormalities in Fragile X knockout mice, suggesting a potential therapeutic role. The study underscores the importance of conducting randomized clinical trials to evaluate minocycline's efficacy and identify any potential side effects.

Navigating the Sands of Fragile X Syndrome: A Guide for Families

This research provides valuable insights into the potential of minocycline as a therapeutic agent for Fragile X syndrome. The study highlights the drug's ability to rescue dendritic spine and synaptic structural abnormalities in Fragile X knockout mice, suggesting a potential therapeutic role. However, the authors also emphasize the importance of conducting randomized clinical trials to evaluate minocycline's efficacy and identify any potential side effects. This information can empower families to engage in informed discussions with their healthcare providers and make well-informed decisions regarding treatment options.

Dr. Camel's Conclusion

The study explores the potential therapeutic benefits of minocycline in the treatment of Fragile X syndrome, highlighting the drug's ability to rescue dendritic spine and synaptic structural abnormalities in Fragile X knockout mice. However, the authors emphasize the importance of conducting randomized clinical trials to definitively evaluate minocycline's efficacy and safety in human patients.

Date :
  1. Date Completed 2010-10-25
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20687826

DOI: Digital Object Identifier

NIHMS577663

Related Literature

Article Analysis
・Side Effects of minocycline
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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