Paper Details 
Original Abstract of the Article :
Plasminogen activator (PA) activity has been suggested to be an important determinant of cell migration and tissue modelling during organogenesis. We have postulated that in the developing embryo, any abnormal modulation of this enzymatic activity may lead to the production of teratogenic effects. I...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元:
https://doi.org/10.1016/0887-2333(93)90077-i

データ提供:米国国立医学図書館(NLM)

The Mystery of Plasminogen Activator: A Desert of Development

The [embryonic development] process is a marvel of nature, with precise orchestration of cell growth and migration. This research investigates the role of [plasminogen activator (PA)] activity in this intricate dance. The researchers explored the effects of teratogenic doses of [retinoic acid], [auranofin], and [mercuric chloride] on PA activity in [post-implantation cultured mouse embryos]. They observed variations in PA activity levels in malformed embryos compared to normal embryos, suggesting a potential link between PA activity and developmental abnormalities.

PA Activity: A Potential Key to Embryonic Development

The study found an increased PA activity in malformed embryos treated with mercuric chloride. PA activity was also slightly increased in both normal and malformed embryos exposed to retinoic acid. These findings suggest that PA activity could play a role in developmental processes, and its disruption might contribute to embryonic malformations.

Understanding PA Activity: A Desert Oasis in Embryonic Development

This research sheds light on the complex interplay between PA activity and embryonic development. Further investigation is needed to fully understand the precise mechanisms and potential implications of PA activity in normal and abnormal embryonic development.

Dr.Camel's Conclusion

This research is like a sandstorm in the desert of embryonic development, uncovering a potential connection between PA activity and developmental abnormalities. It reminds us of the delicate balance required for a healthy embryo to thrive.

Date :
  1. Date Completed 2012-10-02
  2. Date Revised 2019-09-18
Further Info :

Pubmed ID

20732276

DOI: Digital Object Identifier

10.1016/0887-2333(93)90077-i

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Languages

English

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