Problems in the management of chronic hepatitis B with interferon: experience in a randomized, multicentre study.

Author: CareddaF, CriscuoloD, FattovichG, MaladornoD, MoroniM, NoventaF, PastoreG, RealdiG, RuggeM, SantantonioT

Paper Details 
Original Abstract of the Article :
In a multicentre trial, 82 patients known to be hepatitis B e antigen and hepatitis B virus DNA positive for at least 1 year, with elevated serum alanine aminotransferase levels and chronic liver lesions on biopsy, were randomized to receive either recombinant interferon alfa-2a at a dose of 4.5 mil...See full text at original site
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引用元:
https://doi.org/10.1016/0168-8278(90)90179-u

データ提供:米国国立医学図書館(NLM)

Navigating the Challenges of Chronic Hepatitis B Treatment: A Journey with Interferon

The battle against chronic hepatitis B, like a tireless struggle against a relentless desert storm, demands innovative and effective treatment strategies. This research, like a medical expedition seeking to conquer a formidable foe, investigates the efficacy of interferon alfa-2a in managing chronic hepatitis B. The authors, like seasoned clinicians, conducted a randomized, multicenter trial involving 82 patients with chronic hepatitis B, comparing the outcomes of those treated with interferon to those who received no treatment. The study's findings, like a desert oasis revealing its secrets, unveil that interferon alfa-2a demonstrates significant effectiveness in clearing the hepatitis B virus from the bloodstream and improving liver function. However, the study, like a desert journey with unexpected twists and turns, highlights the challenges of achieving sustained viral suppression, with a significant proportion of patients experiencing viral reactivation following treatment. The authors, like astute navigators, carefully analyze these findings, emphasizing the need for more prolonged treatment regimens and personalized approaches to effectively manage chronic hepatitis B.

The Importance of Personalized Treatment Strategies for Hepatitis B

The study's findings emphasize the importance of individualized treatment strategies for chronic hepatitis B. This knowledge, like a wellspring of wisdom in the desert, enables us to tailor treatment approaches to each patient's unique needs and circumstances, maximizing their chance of a successful outcome.

A Journey Towards Effective Hepatitis B Management

This research underscores the importance of continuous exploration in the field of hepatitis B treatment. By refining treatment strategies and developing innovative therapies, we can provide effective and safe care for patients grappling with this condition. The study's findings serve as a compass guiding us towards a more individualized and personalized approach to hepatitis B management.

Dr.Camel's Conclusion

This research, like a camel traversing the desert of hepatitis B treatment, explores the complex interplay of interferon alfa-2a and viral reactivation. The findings highlight the importance of individualized treatment approaches, recognizing the unique needs of each patient. This knowledge, like a precious oasis, empowers us to navigate the challenges of chronic hepatitis B and provide optimal care for those in need.

Date :
  1. Date Completed 1991-04-30
  2. Date Revised 2019-08-17
Further Info :

Pubmed ID

2079570

DOI: Digital Object Identifier

10.1016/0168-8278(90)90179-u

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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