Depression in Parkinson's disease: symptom improvement and residual symptoms after acute pharmacologic management.

Author: BienfaitKarina L, DickeAllison, DobkinRoseanne DeFronzo, FriedmanJill, GaraMichael, MarinHumberto, MarkMargery H, MenzaMatthew

Paper Details 
Original Abstract of the Article :
Parkinson's disease (PD) is frequently complicated by depression and there is a paucity of controlled research that can inform the management of this disabling nonmotor complaint. A randomized controlled trial of nortriptyline, paroxetine, and placebo for the treatment of depression in PD (dPD) was ...See full text at original site
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引用元:
https://pubmed.ncbi.nlm.nih.gov/20808132

データ提供:米国国立医学図書館(NLM)

Depression in Parkinson's Disease: Exploring Treatment Responses

Parkinson's disease (PD), a neurodegenerative disorder affecting movement, is often accompanied by depression, significantly impacting quality of life for patients. This study examines the symptom presentation of depression in PD and the specific symptoms that improve with pharmacotherapy. Researchers conducted a randomized controlled trial comparing the effects of nortriptyline, paroxetine, and placebo in treating depression in PD. The study aimed to understand the specific aspects of depression that respond to pharmacotherapy and the residual symptoms that persist after treatment. The findings provide valuable insights into the complexities of depression in PD and the effectiveness of different treatment approaches.

Pharmacotherapy for Depression in PD: A Mixed Bag of Results

The study revealed that while pharmacotherapy can effectively improve certain depressive symptoms in PD, residual symptoms often remain even after achieving a response or remission. This highlights the need for a comprehensive approach to managing depression in PD, potentially incorporating psychotherapy and lifestyle modifications alongside pharmacotherapy. The findings also emphasize the importance of tailoring treatment strategies to the specific symptom presentation of depression in PD.

Managing Depression in Parkinson's Disease: A Multifaceted Approach

If you or a loved one is living with Parkinson's disease and experiencing depression, consult a healthcare professional. Effective management of depression in PD often requires a multifaceted approach, incorporating pharmacotherapy, psychotherapy, and lifestyle modifications. Working closely with a healthcare team can help you develop a tailored treatment plan that addresses your specific needs and improves your overall well-being.

Dr. Camel's Conclusion

This study, like a desert traveler navigating the challenges of Parkinson's disease and depression, highlights the complexities of managing this condition. It reveals that while pharmacotherapy can offer relief, a multi-faceted approach is often needed to address the diverse aspects of depression in PD. By understanding the individual needs of patients and employing a tailored strategy, we can strive to provide comprehensive care and support, helping those with PD navigate the path towards a more fulfilling life.

Date :
  1. Date Completed 2011-06-14
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20808132

DOI: Digital Object Identifier

NIHMS189878

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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