Paper Details

  1. Home
  2. Paper Details

Antinociceptive effects and toxicity of morphine-6-O-sulfate sodium salt in rat models of pain.

Author: CrooksPeter A, HoltmanJoseph R, Johnson-HardyJaime, WalaElzbieta P

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Morphine-6-O-sulfate, a morphine derivative, was found to be effective in treating acute nociceptive, neuropathic and inflammatory pain in rats. The drug was effective through different administration routes and had a good separation between analgesic effects and side effects, including incoordination, hypolocomotion, and inhibition of gastrointestinal motility. Morphine-6-O-sulfate is a potential candidate for the development of a novel opioid for pain management.
Paper Details　
Original Abstract of the Article :
Mu-opioids (i.e. morphine, oxycodone, hydrocodone) are considered to be the primary drugs for treatment of moderate to severe acute, chronic and cancer pain. Despite their analgesic effectiveness they have several clinically significant side-effects (cognitive, motor, respiratory, cardiovascular, ga...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1016/j.ejphar.2010.08.034

データ提供：米国国立医学図書館（NLM）

Antinociceptive Effects and Toxicity of Morphine-6-O-sulfate Sodium Salt in Rat Models of Pain

As a researcher delving into the complex world of pain management, I find the development of new analgesics with improved efficacy and fewer side effects particularly intriguing. This study explores the antinociceptive effects and toxicity of morphine-6-O-sulfate, a morphine derivative, in rat models of pain. The authors demonstrate that morphine-6-O-sulfate exhibits potent analgesic activity against various pain types, including acute, neuropathic, and inflammatory pain, while exhibiting a favorable safety profile compared to conventional morphine. This study suggests that morphine-6-O-sulfate holds potential as a novel opioid for managing pain with a better side-effect profile.

A New Oasis in the Desert of Pain Management

This research unveils the potential of morphine-6-O-sulfate as a novel analgesic with a favorable safety profile. This compound, a modified form of morphine, demonstrates potent analgesic effects across different pain types, while exhibiting a promising separation between analgesic efficacy and side effects. This finding suggests that morphine-6-O-sulfate could offer a valuable alternative to traditional morphine, potentially improving the quality of pain management and reducing the burden of side effects for patients.

Navigating the Sands of Pain Relief

This study opens a new avenue for pain management by exploring the potential of morphine-6-O-sulfate, a novel compound with promising analgesic properties. This finding can help guide the development of new pain medications with improved efficacy and reduced side effects, potentially easing the suffering of individuals navigating the harsh desert of chronic pain.

Dr. Camel's Conclusion

This research highlights the promising potential of morphine-6-O-sulfate as a novel analgesic with a favorable safety profile. This study provides valuable insight into the development of new pain medications with potentially improved efficacy and reduced side effects, paving the way for a brighter future in pain management.

Date :
  1. Date Completed 2011-01-21
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

20828549

DOI: Digital Object Identifier

10.1016/j.ejphar.2010.08.034

Related Literature

Article Analysis
・Side Effects of hydrocodone
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.