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Pharmacodynamic effects of concomitant versus staggered clopidogrel and omeprazole intake: results of a prospective randomized crossover study.

Author: AngiolilloDominick J, BassTheodore A, CapodannoDavide, CharltonRonald K, DarlingtonAndrew, DesaiBhaloo, DharmashankarKodlipet, FerreiroJosé L, UenoMasafumi

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Omeprazole impaired clopidogrel-induced antiplatelet effects in the maintenance phase of treatment, regardless of the timing of their administration.
Paper Details　
Original Abstract of the Article :
BACKGROUND: A drug interaction between clopidogrel and omeprazole resulting in impaired platelet inhibition has been reported. It has been suggested that staggering administration of clopidogrel and omeprazole may overcome this pharmacodynamic (PD) interaction. METHODS AND RESULTS: This prospective...See full text at original site
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引用元：
https://doi.org/10.1161/CIRCINTERVENTIONS.110.957829

データ提供：米国国立医学図書館（NLM）

Clopidogrel and Omeprazole: A Delicate Dance in the Desert of Drug Interactions

The world of drug interactions is a complex desert, where seemingly unrelated medications can collide in unexpected ways. This study focuses on the interaction between clopidogrel, a platelet inhibitor, and omeprazole, a proton pump inhibitor, commonly used to treat heartburn. The study investigates whether staggering the administration of these two drugs can mitigate the potential for a pharmacodynamic interaction.

A Complex Oasis: Concomitant vs. Staggered Administration

The study's findings, like a mirage in the desert, are somewhat perplexing. While previous research suggested that staggering clopidogrel and omeprazole administration could improve platelet inhibition, this study did not find significant differences between concomitant and staggered regimens.

Navigating the Desert of Drug Interactions: Cautious Optimism

The results, while not conclusive, highlight the importance of carefully considering potential drug interactions. Doctors and patients should remain vigilant and consult with healthcare professionals to ensure safe and effective medication management.

Dr.Camel's Conclusion

The interplay of medications can be as unpredictable as a desert sandstorm. This study underscores the importance of understanding potential drug interactions and seeking professional guidance to navigate this complex landscape safely.

Date :
  1. Date Completed 2011-05-24
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20858862

DOI: Digital Object Identifier

10.1161/CIRCINTERVENTIONS.110.957829

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PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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