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Effects of multiple-dose esomeprazole and pantoprazole on diazepam pharmacokinetic profile and pharmacodynamic effects on cognitive and psychomotor function in healthy volunteers.
Author: BethkeThomas D, DrewelowBernd, ReitmeirPeter, SchafflerKlaus
Original Abstract of the Article :
A randomized, double-blind, 2-way crossover trial of 24 healthy volunteers investigated the influence of esomeprazole (CAS 119141-88-7) and pantoprazole (CAS 102625-70-7), both 1 x 40 mg orally for 11 days, on the pharmacokinetics and pharmacodynamics of diazepam (CAS 439-14-5). Single-dose intraven...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
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引用元:
https://doi.org/10.1055/s-0031-1296316
データ提供:米国国立医学図書館(NLM)
Effects of Multiple-Dose Esomeprazole and Pantoprazole on Diazepam Pharmacokinetic Profile and Pharmacodynamic Effects on Cognitive and Psychomotor Function in Healthy Volunteers
Imagine a camel caravan crossing a vast desert, each camel representing a different medication. This research investigates the interaction between two common medications, esomeprazole and pantoprazole, both proton pump inhibitors, and diazepam, a benzodiazepine used for anxiety and sleep disorders. It examines how these medications affect each other's pharmacokinetics and pharmacodynamics, which is similar to studying how different camels in a caravan interact and influence each other's journey. This research provides valuable insights into potential drug interactions, ensuring safe and effective medication use.
The Impact of Drug Interactions
This study reveals a potential interaction between esomeprazole and diazepam. The study found that esomeprazole significantly increased the levels of diazepam in the body, suggesting that these medications may not be compatible. It's like a camel struggling to carry a heavy load, potentially slowing down the caravan's progress. This research highlights the importance of understanding drug interactions to minimize potential risks and optimize medication safety.
Navigating the Complexities of Medication Use
This research underscores the importance of careful medication use, especially when combining different drugs. It emphasizes the need for doctors and pharmacists to consider potential drug interactions, especially when prescribing medications for patients with multiple health concerns. This study, like a compass guiding a caravan through the desert, provides valuable information for safe and effective medication use.
Dr. Camel's Conclusion
This study reveals a potential drug interaction between esomeprazole and diazepam. Just like a camel carrying a heavy load, this interaction could lead to unexpected and potentially harmful consequences. This research emphasizes the importance of understanding and managing drug interactions for safe and effective medication use.
Date :
- Date Completed 2010-10-21
- Date Revised 2018-12-01
Further Info :
Related Literature
English
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