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Impact of treatments for postmenopausal osteoporosis (bisphosphonates, parathyroid hormone, strontium ranelate, and denosumab) on bone quality: a systematic review.

Author: DixonT, GallacherS J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This review examined the effects of various osteoporosis treatments on bone quality. Teriparatide, a hormone, increases bone formation and improves bone structure. Bisphosphonates decrease bone breakdown, improving bone architecture, but there are concerns that long-term use might interfere with bone repair. Strontium ranelate increases bone formation and decreases bone breakdown, improving bone thickness and structure. Denosumab rapidly reduces bone breakdown. For women aged 60-65 with very low bone density, teriparatide may be the best initial treatment to improve bone quality. After teriparatide, bisphosphonates can help maintain improvements and reduce fracture risk.
Paper Details　
Original Abstract of the Article :
The objective of this systematic review was to examine the influence of treatments for postmenopausal osteoporosis (parathyroid hormone [PTH], bisphosphonates, strontium ranelate, and denosumab) on bone quality and discuss the clinical implications. Most bone-quality data for PTH is from teriparatid...See full text at original site
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引用元：
https://doi.org/10.1007/s00223-010-9420-x

データ提供：米国国立医学図書館（NLM）

Postmenopausal Osteoporosis Treatments: A Focus on Bone Quality

This research delves into the world of endocrinology, focusing on the treatment of postmenopausal osteoporosis, a condition that weakens bones and increases fracture risk. The study examines the impact of various treatments on bone quality, providing insights into their effectiveness in restoring and preserving bone health.

Treatments for Postmenopausal Osteoporosis: Building Stronger Bones

The study reviews the effects of different treatments, including parathyroid hormone (PTH), bisphosphonates, strontium ranelate, and denosumab, on bone quality. It reveals that each treatment has a distinct mechanism of action and a unique impact on bone structure, highlighting the importance of individualizing treatment strategies based on patient needs and risk factors.

Maintaining Bone Health: A Lifelong Journey

This research underscores the importance of addressing osteoporosis in postmenopausal women. It emphasizes the need for personalized treatment strategies and ongoing monitoring to ensure bone health and reduce fracture risk.

Dr.Camel's Conclusion

This study showcases the multifaceted nature of osteoporosis treatment, much like the desert's diverse landscape. Understanding the impact of various treatments on bone quality allows healthcare professionals to navigate the path toward stronger bones for postmenopausal women.

Date :
  1. Date Completed 2011-03-14
  2. Date Revised 2018-12-01
Further Info :

Pubmed ID

20872215

DOI: Digital Object Identifier

10.1007/s00223-010-9420-x

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・Effective treatment of osteoporosis
SNS
PICO Info
in preparation
Languages

English

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