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Experience with interferon in chronic hepatitis B in Egypt.

Author: Abd el FattahS, AminM, OsmanL M, SabbourM S, WakedI

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effectiveness of interferon-alpha 2b treatment to no treatment in 40 patients with chronic hepatitis B. Interferon treatment significantly increased the rate of clearing the virus, with 81% of treated patients experiencing viral clearance compared to 33% in the control group. While both treatment groups showed changes in other viral markers, these changes were more frequent in the interferon group. The study found that the duration of hepatitis B infection influenced the effectiveness of treatment, with those who had the virus for shorter periods experiencing a greater response. While interferon was effective in improving liver function, a significant increase in liver enzymes during treatment was associated with liver failure in a few cases.
Paper Details　
Original Abstract of the Article :
Forty patients with compensated chronic active hepatitis B and elevated aminotransferases who were HBsAg and HBeAg positive were randomised to a treatment group receiving recombinant interferon alpha-2b (rIFN alpha-2b) or no treatment as a control group. The treated patients were divided into 2 grou...See full text at original site
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引用元：
https://doi.org/10.1080/1120009x.1990.11739035

データ提供：米国国立医学図書館（NLM）

Investigating the Effectiveness of Interferon in Chronic Hepatitis B in Egypt

This study delves into the realm of chronic hepatitis B, a persistent liver infection, and its treatment with interferon in Egypt. Like a seasoned explorer traversing the vast desert of medical research, the authors set out to discover the efficacy of interferon alpha-2b in combating the disease. The study employed a randomized controlled trial design, a reliable method for comparing treatment groups. Their journey led them to uncover some noteworthy findings, particularly the significant association between interferon therapy and HBeAg clearance, a crucial marker for disease control.

Interferon Therapy Shows Promise in Chronic Hepatitis B

The study's results paint a positive picture, highlighting the potential of interferon in treating chronic hepatitis B. Among the patients who received interferon, a remarkable 81% experienced HBeAg clearance, significantly higher than the 33% observed in the control group. This success story is further supported by the impressive reduction in biochemical and histological activity in patients who achieved a complete response, characterized by the disappearance of HBsAg.

Interferon: A Potential Tool in the Fight Against Chronic Hepatitis B

The findings suggest that interferon could be a valuable tool in combating chronic hepatitis B, particularly when considering the potential for HBeAg clearance and improvement in liver health. However, it's important to remember that the journey to cure this disease is complex and requires further exploration. This study, like a shining oasis in the desert of medical knowledge, provides valuable insights, but more research is needed to fully understand the long-term impact of interferon therapy and to explore other potential treatment strategies.

Dr. Camel's Conclusion

As a seasoned researcher, I've seen firsthand the transformative power of medical advancements. The results of this study, like a refreshing breeze in the desert, offer hope for individuals battling chronic hepatitis B. However, remember that while interferon shows promise, it's not a magic bullet. Like a wise traveler in the desert, always consult your physician to determine the best course of action for your individual needs.

Date :
  1. Date Completed 1991-06-03
  2. Date Revised 2019-10-29
Further Info :

Pubmed ID

2090770

DOI: Digital Object Identifier

10.1080/1120009x.1990.11739035

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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