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Treatment of moderate to severe restless legs syndrome: 2-year safety and efficacy of rotigotine transdermal patch.

Author: BenešHeike, García-BorregueroDiego, GeislerPeter, HöglBirgit, KohnenRalf, OertelWolfgang H, PoeweWerner, SchollmayerErwin, Stiasny-KolsterKarin, TrenkwalderClaudia

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Transdermal rotigotine, a dopamine agonist, was safe and effective in treating moderate to severe restless legs syndrome (RLS) for up to 2 years.
Paper Details　
Original Abstract of the Article :
Rotigotine is a unique dopamine agonist with activity across D1 through D5 receptors as well as select adrenergic and serotonergic sites. This study reports the 2-year follow-up safety and efficacy data of an ongoing open-label multicenter extension study (NCT00498186) of transdermal rotigotine in p...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2958158/

データ提供：米国国立医学図書館（NLM）

Rotigotine Transdermal Patch: A Long-Term Treatment for Restless Legs Syndrome

The unsettling feeling of restless legs syndrome (RLS), characterized by an irresistible urge to move the legs, can significantly impact sleep quality and overall well-being. This study examines the long-term safety and efficacy of rotigotine, a unique dopamine agonist delivered via a transdermal patch, in patients with moderate to severe RLS. The researchers conducted an open-label multicenter extension study, evaluating the treatment's effects over a two-year period.

Long-Term Effectiveness: Rotigotine's Sustained Benefits in RLS

The study demonstrated the long-term effectiveness of rotigotine in managing RLS, with sustained benefits over two years. The researchers observed a significant improvement in RLS symptoms, with patients experiencing a reduction in the urge to move, leg discomfort, and sleep disturbances. Importantly, the study also highlighted the favorable safety profile of rotigotine, with minimal adverse events reported during the two-year follow-up period.

Navigating the Desert of Restless Legs: A Hope for Improved Sleep and Quality of Life

This study provides a promising avenue for long-term management of RLS, offering hope for improved sleep quality and overall well-being. The sustained effectiveness and favorable safety profile of rotigotine underscore its potential as a valuable treatment option for individuals living with RLS. This research highlights the importance of continued exploration of novel therapies for RLS, striving to improve the lives of those affected by this debilitating condition.

Dr.Camel's Conclusion

This study demonstrates the long-term safety and efficacy of rotigotine transdermal patch for treating moderate to severe restless legs syndrome. Rotigotine provides sustained benefits in reducing symptoms and improving sleep quality, making it a promising option for long-term management of RLS.

Date :
  1. Date Completed 2011-01-06
  2. Date Revised 2021-10-20
Further Info :

Pubmed ID

20920156

DOI: Digital Object Identifier

PMC2958158

Related Literature

Article Analysis
・Side Effects of rotigotine transdermal patch
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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