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Molecular basis of hypertension side effects induced by sunitinib.

Author: Afonso-AfonsoFrancisco J, Antón-AparicioLuis M, Aparicio-GallegoGuadalupe, Campos-BaleaBegoña, Fernández-CalvoOvidio, Fírvida-PérezJose L, León-MateosLuis, Lázaro-QuintelaMartín, Ramos-VázquezManuel, Vázquez-EstévezSergio

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that hypertension is a common adverse effect of therapy with angiogenesis inhibitors, such as tyrosine kinase inhibitors (TKIs). The mechanisms underlying this hypertension are not well known but may involve vascular rarefaction, endothelial dysfunction, and/or altered nitric oxide metabolism.
Paper Details　
Original Abstract of the Article :
Over the past decade a number of vascular complications have emerged, such as newly developed or worsened hypertension, in patients who were administered with new cancer treatments for several types of cancer that were untreatable earlier. Hypertension is emerging as one of the most common adverse e...See full text at original site
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引用元：
https://doi.org/10.1097/CAD.0b013e3283403806

データ提供：米国国立医学図書館（NLM）

The Curious Case of Sunitinib and Hypertension

This study explores the unexpected connection between sunitinib, a targeted cancer therapy, and hypertension. The researchers, like skilled medical detectives, are investigating the mechanisms by which this drug can cause or worsen high blood pressure in cancer patients. They delve into the intricate world of vascular function and angiogenesis, seeking to understand the interplay between sunitinib and the cardiovascular system.

Unveiling the Hidden Side Effects of Cancer Therapies

This study highlights the importance of understanding the potential side effects of cancer therapies, even those that are specifically targeted to kill cancer cells. It underscores the need for careful monitoring and management of blood pressure in patients receiving sunitinib and other angiogenesis inhibitors. This is like uncovering a hidden oasis in the vast desert of cancer therapy, revealing a potentially dangerous side effect that requires attention and management.

Navigating the Desert of Cancer Treatment

This study provides valuable guidance for healthcare providers treating cancer patients with sunitinib and other angiogenesis inhibitors. It emphasizes the importance of carefully monitoring blood pressure and taking steps to manage hypertension, ensuring the best possible outcomes for these patients. This is like finding a safe path through the treacherous desert of cancer treatment, guiding patients and providers towards a successful journey.

Dr. Camel's Conclusion

This study sheds light on the complex relationship between cancer therapies and cardiovascular health. It underscores the importance of vigilant monitoring and proactive management of hypertension in patients receiving sunitinib and other angiogenesis inhibitors. It's like finding a new trail in the desert of cancer treatment, offering a path towards a more effective and safer journey for patients.

Date :
  1. Date Completed 2011-03-04
  2. Date Revised 2022-03-17
Further Info :

Pubmed ID

20938340

DOI: Digital Object Identifier

10.1097/CAD.0b013e3283403806

Related Literature

Article Analysis
・Side Effects of sunitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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