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N-methyl-D-aspartate receptor-mediated modulations of the anti-allodynic effects of 5-HT1B/1D receptor stimulation in a rat model of trigeminal neuropathic pain.

Author: BourgoinSylvie, HamonMichel, KayserValérie, LatrémolièreAlban

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

The study found that blocking NMDA receptors in rats with trigeminal neuropathic pain enhances the anti-allodynic effects of dihydroergotamine and zolmitriptan. This suggests that a combination of NMDA receptor antagonists and 5-HT(1B/1D)-receptor agonists may be a promising approach for alleviating trigeminal neuropathic pain.
Paper Details　
Original Abstract of the Article :
Previous studies showed that triptans and other 5-HT(1B/1D)-receptor agonists attenuate hyper-responsiveness to mechanical stimulation of the face in a rat model of trigeminal neuropathic pain, probably by activating 5-HT(1B/1D)-receptors on primary afferent nociceptive fibers. We now tested whether...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejpain.2010.09.012

データ提供：米国国立医学図書館（NLM）

Targeting Trigeminal Neuropathic Pain: A Novel Approach

Imagine a desert, where a gentle breeze can transform into a sandstorm in an instant. This research explores a novel approach to managing trigeminal neuropathic pain, a condition characterized by chronic pain in the face.

Modulating the Anti-Allodynic Effects of 5-HT1B/1D Receptor Stimulation

The study focuses on the potential of combining 5-HT1B/1D receptor agonists, drugs that target certain serotonin receptors, with NMDA receptor antagonists, drugs that block the activity of NMDA receptors. This combination approach could potentially enhance the pain-relieving effects of 5-HT1B/1D receptor agonists.

Promising Results for Trigeminal Neuropathic Pain

The researchers found that blocking NMDA receptors significantly potentiated the anti-allodynic effects of 5-HT1B/1D receptor agonists in a rat model of trigeminal neuropathic pain. This finding suggests that combining these two types of drugs could be a promising approach for treating this challenging condition.

Dr. Camel's Conclusion

This research offers a glimmer of hope for patients suffering from trigeminal neuropathic pain. By combining different drug classes, we might be able to control this unpredictable pain, just as a desert traveler uses various strategies to navigate changing weather conditions.

Date :
  1. Date Completed 2011-09-15
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

20965753

DOI: Digital Object Identifier

10.1016/j.ejpain.2010.09.012

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Article Analysis
・Effects of zolmitriptan
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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