Paper Details

  1. Home
  2. Paper Details

Effects of fenofibrate on renal function in patients with type 2 diabetes mellitus: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) Study.

Author: , BestJ D, DavisT M E, DonoghoeM W, DruryP L, GebskiV J, GlasziouP P, JenkinsA J, KeechA C, KesäniemiY A, O'ConnellR L, ScottR S, SimesR J, SullivanD R, TingR, WhitingM J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the renal effects of fenofibrate in type 2 diabetic patients. Fenofibrate reduced albuminuria and slowed estimated GFR loss over 5 years, despite initially increasing plasma creatinine. Fenofibrate may delay albuminuria and GFR impairment in type 2 diabetes patients.
Paper Details　
Original Abstract of the Article :
AIMS/HYPOTHESIS: Fenofibrate caused an acute, sustained plasma creatinine increase in the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) and Action to Control Cardiovascular Risk in Diabetes (ACCORD) studies. We assessed fenofibrate's renal effects overall and in a FIELD washout sub...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1007/s00125-010-1951-1

データ提供：米国国立医学図書館（NLM）

Fenofibrate: A Double-Edged Sword for Diabetic Kidney Disease?

Type 2 diabetes is a chronic condition that affects millions worldwide. This study explores the impact of fenofibrate, a medication used to lower triglycerides and raise HDL cholesterol, on renal function in patients with type 2 diabetes. The researchers conducted a large-scale clinical trial, the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study, to investigate the long-term effects of fenofibrate on renal function.

Fenofibrate: A Complex Relationship with Kidney Health

The study found that fenofibrate initially increased plasma creatinine levels, a marker of kidney function. However, this increase was transient and reversed upon discontinuation of the drug. Despite the initial increase in creatinine, fenofibrate was associated with a slower rate of estimated GFR loss and reduced albuminuria over a 5-year period. This suggests that fenofibrate may have a complex effect on renal function, with both potential risks and benefits.

Navigating the Desert of Diabetic Kidney Disease

Imagine a camel traversing a desert, facing the threat of dehydration and kidney failure. Fenofibrate, in this analogy, could be like a source of water, offering potential benefits but also carrying the risk of dehydration if not carefully managed. This study reminds us that the treatment of diabetic kidney disease is a delicate balancing act, requiring careful monitoring and a personalized approach.

Dr.Camel's Conclusion

This study highlights the complexity of managing diabetic kidney disease. While fenofibrate may offer benefits in reducing albuminuria and slowing GFR loss, it's important to be aware of its potential impact on renal function. It's a reminder that the desert of chronic disease is a challenging landscape, requiring constant vigilance and a collaborative effort between healthcare professionals and patients.

Date :
  1. Date Completed 2011-05-02
  2. Date Revised 2022-04-10
Further Info :

Pubmed ID

21052978

DOI: Digital Object Identifier

10.1007/s00125-010-1951-1

Related Literature

Article Analysis
・Effects of ethosuximide・Effects of fenofibrate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.