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Reversal of refractory sulfasalazine-related renal failure after treatment with corticosteroids.

Author: AlivanisPolichronis, AperisGeorgios, ArvanitisAntonios, KarvouniarisNikolaos, LambrianouFotini, PaliourasChristos, ZervosAngelos

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

Sulfasalazine-related interstitial nephritis can occur even after prolonged use. Corticosteroids may be effective in treating this condition, but further research is needed.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Sulfasalazine is a combination of sulfapyridine and 5-aminosalicylic acid and is used as a first-line treatment in inflammatory bowel disease. OBJECTIVE: We describe a case of acute interstitial nephritis that presented after 7 months of sulfasalazine therapy. Despite the discontinuatio...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
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引用元：
https://doi.org/10.1016/j.clinthera.2010.10.002

データ提供：米国国立医学図書館（NLM）

Sulfasalazine-Related Renal Failure: A Case Study and Treatment with Corticosteroids

The world of medicine can be like a desert with many unexpected challenges. This case study presents a patient who developed severe kidney problems as a side effect of sulfasalazine, a drug commonly used to treat inflammatory bowel disease. It's a reminder that even familiar paths through the desert can hold hidden dangers.

Sulfasalazine-Related Nephrotoxicity and the Role of Corticosteroids

The patient experienced a rapid decline in kidney function after taking sulfasalazine for several months. This led to the diagnosis of acute interstitial nephritis, a condition that causes inflammation in the kidneys. The researchers observed that the patient's kidney function improved dramatically after receiving treatment with corticosteroids.

The Importance of Careful Monitoring and Treatment Options

This case study highlights the importance of careful monitoring for drug side effects. It's like being vigilant for hidden dangers in the desert. The study also suggests that corticosteroids can be effective in treating sulfasalazine-related kidney problems. This provides a potential oasis of hope for patients experiencing this serious side effect.

Dr.Camel's Conclusion

This case study demonstrates the potential for severe side effects from sulfasalazine, even after prolonged use. It also underscores the importance of careful monitoring and prompt treatment with corticosteroids when kidney problems arise. This serves as a valuable lesson in the desert of medical practice, reminding us to be prepared for unexpected challenges and to always seek the best possible care for our patients.

Date :
  1. Date Completed 2011-03-04
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

21095485

DOI: Digital Object Identifier

10.1016/j.clinthera.2010.10.002

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