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Pharmacokinetics and pharmacodynamics of pravastatin alone and with cholestyramine in hypercholesterolemia.

Author: BresciaD, DeVaultA R, IvashkivE, PanH Y, SwitesB J, WhiganD, WillardD A

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Pravastatin, a new selective 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, significantly decreased total cholesterol and low-density lipoprotein cholesterol in patients with primary hypercholesterolemia. Cholestyramine enhanced the lipid-lowering effects of pravastatin.
Paper Details　
Original Abstract of the Article :
The pharmacokinetics, pharmacodynamics, and safety of pravastatin, a new selective 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, were evaluated during monotherapy and with subsequent concomitant cholestyramine therapy in 33 patients with primary hypercholesterolemia in this randomized s...See full text at original site
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引用元：
https://doi.org/10.1038/clpt.1990.136

データ提供：米国国立医学図書館（NLM）

Pravastatin: A Powerful Tool for Lowering Cholesterol

Hypercholesterolemia, or high cholesterol, is a common health concern that can increase the risk of heart disease. This research examines the pharmacokinetics and pharmacodynamics of pravastatin, a new selective 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, evaluating its effectiveness in lowering cholesterol levels and its interactions with other medications. This study is like a journey through the desert of cholesterol management, seeking to find the most effective way to control cholesterol levels and prevent heart disease.

Pravastatin Shows Promising Results in Lowering Cholesterol

The study found that pravastatin effectively lowered total cholesterol and LDL cholesterol levels, showing a dose-dependent effect. This finding is like discovering a hidden spring in the desert, providing a new source of hope for those battling high cholesterol. The study also found that combining pravastatin with cholestyramine enhanced the lipid-lowering effects, suggesting that this combination could be a powerful tool for managing hypercholesterolemia.

Managing Cholesterol Effectively

This research emphasizes the importance of considering the pharmacokinetics and pharmacodynamics of cholesterol-lowering medications when developing personalized treatment plans. It highlights the potential of combining different medications to achieve optimal outcomes. Think of it as a journey through the desert of cholesterol management, where we need to find the best combination of resources to navigate the challenges.

Dr.Camel's Conclusion

This study provides valuable insights into the effectiveness of pravastatin in lowering cholesterol levels and its potential for combination therapy. It emphasizes the importance of understanding the pharmacokinetics and pharmacodynamics of cholesterol-lowering medications to develop individualized treatment plans that optimize outcomes.

Date :
  1. Date Completed 1990-09-12
  2. Date Revised 2019-05-10
Further Info :

Pubmed ID

2116260

DOI: Digital Object Identifier

10.1038/clpt.1990.136

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SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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