Evaluation of adverse effects in tamoxifen exposed healthy female dogs.

Author: BertagnolliAngelica C, CarneiroRubens A, CassaliGeovanni D, CavalcantiGuilherme A O, FigueiredoMariana S, LavalleGleidice E, MeloMarilia M, PaesPaulo R O, SouzaAline G, TavaresWanessa L F, VianaFernando A B

Paper Details 
Original Abstract of the Article :
Mammary tumors are among the most frequent neoplasms in female dogs, but the strategies employed in animal treatment are limited. In human medicine, hormone manipulation is used in cancer therapy. Tamoxifen citrate is a selective inhibitor of oestrogen receptors and exerts a potent anti-oestrogen ef...See full text at original site
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引用元:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3022551/

データ提供:米国国立医学図書館(NLM)

Evaluation of Adverse Effects in Tamoxifen Exposed Healthy Female Dogs

This study investigates the potential adverse effects of tamoxifen, a medication commonly used to treat breast cancer in humans, in healthy female dogs. The research aims to provide insights into the safety of tamoxifen in a species closely related to humans and to assess its suitability for potential use in veterinary medicine.

Tamoxifen's Potential Use in Veterinary Medicine

The study explored the potential use of tamoxifen in veterinary medicine, specifically for the treatment of mammary tumors in female dogs. While tamoxifen has shown promising results in human medicine, the research highlights the importance of careful evaluation before applying it to animals. The study focuses on identifying any potential side effects in healthy dogs to assess the drug's safety profile and guide future research.

Careful Evaluation is Crucial for Drug Safety

The study emphasizes the importance of rigorous testing and evaluation before introducing any medication to new populations, particularly in the context of potential veterinary use. Understanding the potential adverse effects is crucial for ensuring the safety and well-being of animals, and this study serves as a reminder of the importance of thorough research before widespread adoption of new treatments.

Dr.Camel's Conclusion

This research highlights the critical importance of thorough evaluation before introducing new medications to different species, even those closely related to humans. The study underscores the need for careful consideration of potential adverse effects and the importance of understanding the unique physiological characteristics of each species. This research exemplifies the responsible approach to drug development and safety, ensuring the well-being of both human and animal populations.

Date :
  1. Date Completed 2011-04-06
  2. Date Revised 2022-04-09
Further Info :

Pubmed ID

21176231

DOI: Digital Object Identifier

PMC3022551

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Languages

English

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